ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraakEnglish 
    • EnglishEnglish
    • norsknorsk
  • Administration/UB
View Item 
  •   Home
  • Det helsevitenskapelige fakultet
  • Institutt for samfunnsmedisin
  • Artikler, rapporter og annet (samfunnsmedisin)
  • View Item
  •   Home
  • Det helsevitenskapelige fakultet
  • Institutt for samfunnsmedisin
  • Artikler, rapporter og annet (samfunnsmedisin)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition

Permanent link
https://hdl.handle.net/10037/24725
DOI
https://doi.org/10.1158/1055-9965.EPI-20-1726
Thumbnail
View/Open
article.pdf (68.74Kb)
Accepted manuscript version (PDF)
Date
2021-06-01
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Heath, Alicia K; Clasen, Johanna L; Jayanth, Nick P; Jenab, Mazda; Tjønneland, Anne; Petersen, Kristina E N; Overvad, Kim; Srour, Bernard; Katzke, Verena; Bergmann, Manuela M; Schulze, Matthias B; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Catalano, A; Pasanisi, Fabrizio; Brustad, Magritt; Olsen, Karina Standahl; Skeie, Guri; Lujan-Barroso, Leila; RodrÍguez-Barranco, Miguel; Amiano, Pilar; Santiuste, Carmen; Gurrea, Aurelio Barricarte; Axelson, Håkon; Ramne, Stina; Ljungberg, Börje; Watts, Eleanor L.; Huybrechts, Inge; Weiderpass, Elisabete; Riboli, Elio; Muller, David C
Abstract
Background: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Methods: A total of 389,220 EPIC participants with median age of 52 years at recruitment (1991–2000) were included. Cox regression yielded adjusted HRs and 95% confidence intervals (CI) for RCC incidence and mortality in relation to intakes of juices and total, sugar-sweetened, and artificially sweetened soft drinks.

Results: A total of 888 incident RCCs and 356 RCC deaths were identified. In models including adjustment for body mass index and energy intake, there was no higher risk of incident RCC associated with consumption of juices (HR per 100 g/day increment = 1.03; 95% CI, 0.97–1.09), total soft drinks (HR = 1.01; 95% CI, 0.98–1.05), sugar-sweetened soft drinks (HR = 0.99; 95% CI, 0.94–1.05), or artificially sweetened soft drinks (HR = 1.02; 95% CI, 0.96–1.08). In these fully adjusted models, none of the beverages was associated with RCC mortality (HR, 95% CI per 100 g/day increment 1.06, 0.97–1.16; 1.03, 0.98–1.09; 0.97, 0.89–1.07; and 1.06, 0.99–1.14, respectively).

Conclusions: Consumption of juices or soft drinks was not associated with RCC incidence or mortality after adjusting for obesity.

Impact: Soft drink and juice intakes are unlikely to play an independent role in RCC development or mortality.

Publisher
American Association for Cancer Research
Citation
Heath AK, Clasen, Jayanth, Jenab M, Tjønneland A, Petersen KEN, Overvad K, Srour B, Katzke V, Bergmann MM, Schulze MB, Masala G, Krogh V, Tumino R, Catalano A, Pasanisi, Brustad M, Olsen KS, Skeie G, Lujan-Barroso L, RodrÍguez-Barranco M, Amiano P, Santiuste C, Gurrea AB, Axelson, Ramne S, Ljungberg B, Watts EL, Huybrechts I, Weiderpass E, Riboli E, Muller DC. Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers and Prevention. 2021;30(6):1270-1274
Metadata
Show full item record
Collections
  • Artikler, rapporter og annet (samfunnsmedisin) [1516]
Copyright 2021 The Author(s)

Browse

Browse all of MuninCommunities & CollectionsAuthor listTitlesBy Issue DateBrowse this CollectionAuthor listTitlesBy Issue Date
Login

Statistics

View Usage Statistics
UiT

Munin is powered by DSpace

UiT The Arctic University of Norway
The University Library
uit.no/ub - munin@ub.uit.no

Accessibility statement (Norwegian only)