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dc.contributor.authorPerrino, Cinzia
dc.contributor.authorBarabási, Albert-Laszló
dc.contributor.authorCondorelli, Gianluigi
dc.contributor.authorDavidson, Sean Michael
dc.contributor.authorDe Windt, Leon
dc.contributor.authorDimmeler, Stefanie
dc.contributor.authorEngel, Felix Benedikt
dc.contributor.authorHausenloy, Derek John
dc.contributor.authorHill, Joseph Addison
dc.contributor.authorVan Laake, Linda Wilhelmina
dc.contributor.authorLecour, Sandrine
dc.contributor.authorLeor, Jonathan
dc.contributor.authorMadonna, Rosalinda
dc.contributor.authorMayr, Manuel
dc.contributor.authorPrunier, Fabrice
dc.contributor.authorSluijter, Joost Petrus Geradus
dc.contributor.authorSchulz, Rainer
dc.contributor.authorThum, Thomas
dc.contributor.authorFerdinandy, Péter
dc.date.accessioned2022-04-27T08:39:48Z
dc.date.available2022-04-27T08:39:48Z
dc.date.issued2017-04-29
dc.description.abstractDespite advances in myocardial reperfusion therapies, acute myocardial ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardioprotective or regenerative therapy has yet to be successfully introduced in the clinical arena. Given the complex pathophysiology of the ischaemic heart, large scale, unbiased, global approaches capable of identifying multiple branches of the signalling networks activated in the ischaemic/reperfused heart might be more successful in the search for novel diagnostic or therapeutic targets. High-throughput techniques allow high-resolution, genome-wide investigation of genetic variants, epigenetic modifications, and associated gene expression profiles. Platforms such as proteomics and metabolomics (not described here in detail) also offer simultaneous readouts of hundreds of proteins and metabolites. Isolated omics analyses usually provide Big Data requiring large data storage, advanced computational resources and complex bioinformatics tools. The possibility of integrating different omics approaches gives new hope to better understand the molecular circuitry activated by myocardial ischaemia, putting it in the context of the human ‘diseasome’. Since modifications of cardiac gene expression have been consistently linked to pathophysiology of the ischaemic heart, the integration of epigenomic and transcriptomic data seems a promising approach to identify crucial disease networks. Thus, the scope of this Position Paper will be to highlight potentials and limitations of these approaches, and to provide recommendations to optimize the search for novel diagnostic or therapeutic targets for acute ischaemia/reperfusion injury and ischaemic heart failure in the post-genomic era.en_US
dc.identifier.citationPerrino C, Barabási, Condorelli G, Davidson, De Windt, Dimmeler S, Engel, Hausenloy, Hill, Van Laake, Lecour S, Leor J, Madonna R, Mayr, Prunier F, Sluijter, Schulz R, Thum T, Ytrehus k, Ferdinandy P. Epigenomic and transcriptomic approaches in the post-genomic era: Path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovascular Research (CVR). 2017;113(7):725-736en_US
dc.identifier.cristinIDFRIDAID 1541139
dc.identifier.doi10.1093/cvr/cvx070
dc.identifier.issn0008-6363
dc.identifier.issn1755-3245
dc.identifier.urihttps://hdl.handle.net/10037/24902
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalCardiovascular Research (CVR)
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/294609/EU/Epigenetics and microRNAs in Myocardial Function and Disease/CARDIOEPIGEN/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/311549/EU/RNA-based regulation of signal transduction–Regulation of calcineurin/NFAT signaling by microRNA-based mechanisms/ALCOHOLLIFECOURSE/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2017 The Author(s)en_US
dc.titleEpigenomic and transcriptomic approaches in the post-genomic era: Path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Hearten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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