Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
Permanent link
https://hdl.handle.net/10037/24903Date
2017-11-02Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Sluijter, Joost Petrus Geradus; Davidson, Sean Michael; Boulanger, Chantal M; Buzas, Edit Iren; De Kleijn, Dominique P.V.; Engel, Felix Benedikt; Giricz, Zoltán; Hausenloy, Derek J.; Kishore, Raj; Lecour, Sandrine; Leor, Jonathan; Madonna, Rosalinda; Perrino, Cinzia; Prunier, Fabrice; Sahoo, Susmita; Schiffelers, Ray Michel; Schulz, Rainer; Van Laake, Linda Wilhelmina; Ytrehus, Kirsti; Ferdinandy, PéterAbstract
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting considerable interest in
the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting
regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including
blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis,
and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects
of cells, and have therefore been proposed as a potential alternative to cell-based regenerative therapies.
Moreover, EVs of different sources may be useful biomarkers of cardiovascular disease identities. However, the
methods used for the detection and isolation of EVs have several limitations and vary widely between studies, leading to uncertainties regarding the exact population of EVs studied and how to interpret the data. The number of
publications in the exosome and MV field has been increasing exponentially in recent years and, therefore, in this
ESC Working Group Position Paper, the overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart. This should help
to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the
diagnostic and therapeutic use of EVs in clinical studies for patient benefit.
Publisher
Oxford University PressCitation
Sluijter JPG, Davidson SM, Boulanger CM, Buzas, De Kleijn DP, Engel FB, Giricz Z, Hausenloy DJ, Kishore, Lecour S, Leor J, Madonna R, Perrino C, Prunier F, Sahoo S, Schiffelers, Schulz R, Van Laake LW, Ytrehus k, Ferdinandy P. Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology. Cardiovascular Research (CVR). 2018;114(1):19-34Metadata
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