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dc.contributor.authorColijn, Johanna M.
dc.contributor.authorBuitendijk, Gabriëlle H.S.
dc.contributor.authorProkofyeva, Elena
dc.contributor.authorAlves, Dalila
dc.contributor.authorCachulo, Maria L.
dc.contributor.authorKhawaja, Anthony P.
dc.contributor.authorCougnard-Gregoire, Audrey
dc.contributor.authorMerle, Bénédicte M.J.
dc.contributor.authorKorb, Christina
dc.contributor.authorErke, Maja Gran
dc.contributor.authorBron, Alain
dc.contributor.authorAnastasopoulos, Eleftherios
dc.contributor.authorMeester-Smoor, Magda A.
dc.contributor.authorSegato, Tatiana
dc.contributor.authorPiermarocchi, Stefano
dc.contributor.authorde Jong, Paulus T.V.M.
dc.contributor.authorVingerling, Johannes R.
dc.contributor.authorTopouzis, Fotis
dc.contributor.authorCreuzot-Garcher, Catherine
dc.contributor.authorPfeiffer, Norbert
dc.contributor.authorFletcher, Astrid E.
dc.contributor.authorFoster, Paul J.
dc.contributor.authorSilva, Rufino
dc.contributor.authorKorobelnik, Jean-François
dc.contributor.authorDelcourt, Cécile
dc.contributor.authorKlaver, Caroline C.W.
dc.date.accessioned2022-04-29T13:47:19Z
dc.date.available2022-04-29T13:47:19Z
dc.date.issued2017-07-14
dc.description.abstractPurpose: Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future.<p> <p>Design: Meta-analysis of prevalence data. Participants: A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe.<p> <p>Methods: AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV).<p> <p>Main Outcome Measures: Prevalence of early and late AMD, BCVA, and number of AMD cases.<p> <p>Results: Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1%e5.0%) in those aged 55e59 years to 17.6% (95% CI 13.6%e21.5%) in those aged 85 years; for late AMD these figures were 0.1% (95% CI 0.04%e0.3%) and 9.8% (95% CI 6.3%e13.3%), respectively. We observed a decreasing prevalence of late AMD after 2006, which became most prominent after age 70. Prevalences were similar for gender across all age groups except for late AMD in the oldest age category, and a trend was found showing a higher prevalence of CNV in Northern Europe. After 2006, fewer eyes and fewer 80-year-old subjects with CNV were visually impaired (P ¼ 0.016). Projections of AMD showed an almost doubling of affected persons despite a decreasing prevalence. By 2040, the number of individuals in Europe with early AMD will range between 14.9 and 21.5 million, and for late AMD between 3.9 and 4.8 million.<p> <p>Conclusion: We observed a decreasing prevalence of AMD and an improvement in visual acuity in CNV occuring over the past 2 decades in Europe. Healthier lifestyles and implementation of antievascular endothelial growth factor treatment are the most likely explanations. Nevertheless, the numbers of affected subjects will increase considerably in the next 2 decades. AMD continues to remain a significant public health problem among Europeans.en_US
dc.identifier.citationColijn, Buitendijk GH, Prokofyeva E, Alves, Cachulo, Khawaja AP, Cougnard-Gregoire A, Merle, Korb, Erke MG, Bron A, Anastasopoulos E, Meester-Smoor, Segato, Piermarocchi S, de Jong PT, Vingerling JR, Topouzis F, Creuzot-Garcher C, Bertelsen G, Pfeiffer N, Fletcher AE, Foster PJ, Silva R, Korobelnik J, Delcourt C, Klaver CC. Prevalence of age-related macular degeneration in Europe: the past and the future. Ophthalmology (Rochester, Minn.). 2017;124(12):1753-1763en_US
dc.identifier.cristinIDFRIDAID 1565321
dc.identifier.doi10.1016/j.ophtha.2017.05.035
dc.identifier.issn0161-6420
dc.identifier.issn1549-4713
dc.identifier.urihttps://hdl.handle.net/10037/24960
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalOphthalmology (Rochester, Minn.)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2017 The American Academy of Ophthalmologyen_US
dc.titlePrevalence of age-related macular degeneration in Europe: the past and the futureen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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