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dc.contributor.authorKostovski, Emil
dc.contributor.authorDahm, Anders Erik A
dc.contributor.authorMowinckel, Marie-Christine
dc.contributor.authorStranda, Annicke
dc.contributor.authorSkretting, Grethe
dc.contributor.authorØsterud, Bjarne
dc.contributor.authorSandset, Per Morten
dc.contributor.authorIversen, Per Ole
dc.date.accessioned2022-05-02T12:01:34Z
dc.date.available2022-05-02T12:01:34Z
dc.date.issued2015-02-03
dc.description.abstractStudy design: This is a double-blind, randomized, placebo-controlled cross-over study of melatonin in complete tetraplegia.<p> <p>Objectives: Tetraplegic patients have an increased risk of venous thrombosis despite prophylaxis, blunted variations in melatonin and altered circadian variation of several hemostatic markers. To examine whether melatonin could modify the regulation of hemostasis, we measured plasma melatonin and several markers of hemostasis in tetraplegic subjects with or without melatonin supplement.<p> <p>Setting: The study was conducted in the Section for Spinal Cord Injury, Sunnaas Hospital, Nesoddtangen, Norway.<p> <p>Methods: Six subjects with long-standing complete tetraplegia were included in this cross-over study with 2 mg of melatonin or placebo given 4 days before sampling. We also included six able-bodied men without any intervention. Plasma samples were then collected frequently during a 24-h awake/sleep cycle. The plasma concentrations of melatonin and the various markers were analyzed using linear mixed models.<p> <p>Results: The 24-h profiles of prothrombin fragment 1+2 and von Willebrand factor, but not D-dimer, activated FVII, tissue factor pathway inhibitor and plasminogen activator inhibitor type 1, differed (Po0.05) between tetraplegic patients and able-bodied subjects. The absolute plasma concentration of activated FVII was higher (Po0.05) among the able-bodied compared with the tetraplegic groups. Supplementation of melatonin had no impact on these findings.<p> <p>Conclusions: We found differences in circadian variation of several hemostatic markers between able-bodied and tetraplegics. These differences were apparently unrelated to fluctuations in the melatonin concentrations, suggesting little or no role of melatonin in the regulation of hemostasis in tetraplegia.en_US
dc.identifier.citationKostovski E, Dahm AEA, Mowinckel M, Stranda A, Skretting G, Østerud B, Sandset PM, Iversen PO. Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin. Spinal Cord. 2015;53:285-290en_US
dc.identifier.cristinIDFRIDAID 1186954
dc.identifier.doi10.1038/sc.2014.243
dc.identifier.issn1362-4393
dc.identifier.issn1476-5624
dc.identifier.urihttps://hdl.handle.net/10037/24969
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalSpinal Cord
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 International Spinal Cord Societyen_US
dc.titleCircadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatoninen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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