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dc.contributor.authorBešević, Jelena
dc.contributor.authorGunter, Marc J
dc.contributor.authorFortner, Renée T.
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorOnland-Moret, N. Charlotte
dc.contributor.authorDossus, Laure
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHansen, Louise
dc.contributor.authorOvervad, Kim
dc.contributor.authorMesrine, Sylvie
dc.contributor.authorBaglietto, Laura
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorBamia, Christina
dc.contributor.authorMasala, Giovanna
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorTumino, Rosario
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorJareid, Mie
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorDuell, Eric J
dc.contributor.authorSánchez, María-José
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorDias, Joana A.
dc.contributor.authorSonestedt, Emily
dc.contributor.authorIdahl, Annika
dc.contributor.authorLundin, Eva
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorRiboli, Elio
dc.contributor.authorMerritt, Melissa A.
dc.date.accessioned2022-05-09T09:26:45Z
dc.date.available2022-05-09T09:26:45Z
dc.date.issued2015-11-10
dc.description.abstractBackground: Reproductive factors influence the risk of developing epithelial ovarian cancer (EOC), but little is known about their association with survival. We tested whether prediagnostic reproductive factors influenced EOC-specific survival among 1025 invasive EOC cases identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which included 521 330 total participants (approximately 370 000 women) aged 25–70 years at recruitment from 1992 to 2000.<p> <p>Methods: Information on reproductive characteristics was collected at recruitment. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), and multivariable models were adjusted for age and year of diagnosis, body mass index, tumour stage, smoking status and stratified by study centre.<p> <p>Results: After a mean follow-up of 3.6 years (±3.2 s.d.) following EOC diagnosis, 511 (49.9%) of the 1025 women died from EOC. We observed a suggestive survival advantage in menopausal hormone therapy (MHT) users (ever vs never use, HR ¼ 0.80, 95% CI ¼ 0.62–1.03) and a significant survival benefit in long-term MHT users (X5 years use vs never use, HR ¼ 0.70, 95% CI ¼ 0.50–0.99, P<sub>trend</sub> ¼ 0.04). We observed similar results for MHT use when restricting to serous cases. Other reproductive factors, including parity, breastfeeding, oral contraceptive use and age at menarche or menopause, were not associated with EOC-specific mortality risk.en_US
dc.identifier.citationBešević, Gunter MJ, Fortner RT, Tsilidis, Weiderpass E, Onland-Moret NC, Dossus L, Tjønneland A, Hansen L, Overvad K, Mesrine S, Baglietto L, Clavel-Chapelon F, Kaaks R, Aleksandrova K, Boeing H, Trichopoulou A, Lagiou P, Bamia C, Masala G, Agnoli C, Tumino R, Ricceri F, Panico S, Bueno-de-Mesquita HB, Peeters PH, Jareid M, Quirós JR, Duell EJ, Sánchez M, Larrañaga N, Chirlaque M, Barricarte A, Dias, Sonestedt E, Idahl A, Lundin E, Wareham NJ, Khaw K, Travis RC, Rinaldi S, Romieu I, Riboli E, Merritt MA. Reproductive factors and epithelial ovarian cancer survival in the EPIC cohort study. British Journal of Cancer. 2015;113(11):1622-1631en_US
dc.identifier.cristinIDFRIDAID 1332586
dc.identifier.doi10.1038/bjc.2015.377
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/25032
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBritish Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/232997/EU/TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY/TICE/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 Cancer Research UKen_US
dc.titleReproductive factors and epithelial ovarian cancer survival in the EPIC cohort studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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