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dc.contributor.authorAverina, Maria
dc.contributor.authorStylidis, Michael
dc.contributor.authorBrox, Jan
dc.contributor.authorSchirmer, Henrik
dc.date.accessioned2022-05-13T10:48:06Z
dc.date.available2022-05-13T10:48:06Z
dc.date.issued2022-03-23
dc.description.abstractAims The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population.<p> <p>Methods and results Altogether, 1936 participants were randomly selected from the general population Tromsø 7 study in Northern Norway. Diagnostic accuracy (sensitivity, specificity, and negative and positive predictive value) of cardiac markers for echocardiographically defined subclinical HF was evaluated. The receiver-operating characteristic analysis showed that areas under the curve were relatively low (under 0.75) for both NT-proBNP and hs-troponin T, suggesting that the diagnostic accuracy of these biomarkers for subclinical HF was not excellent, especially for mild forms of HF and younger age group 40–49 years. Sex-specific and age-specific cut-offs for hs-troponin T (99th percentiles) and NT-proBNP (97.5th percentiles) were established in healthy subjects from the same general population. The sex-specific and age-specific cut-offs for NT-proBNP had higher specificity for subclinical HF compared with the previously established single cut-off 125 pg/mL. Age-specific cut-off for hs-troponin T (18 ng/L) for men ≥60 years had also higher specificity than the single cut-off 14 ng/L. These cut-offs had high specificity, but low sensitivity, that makes hs-troponin T and NT-proBNP good biomarkers to rule in HF in case of a positive test, but not good enough to rule out all unrecognized HF due to false negative results.<p> <p>Conclusions N-terminal pro-brain natriuretic peptide and hs-troponin T are suboptimal screening tools for subclinical HF in a general population due to low sensitivity.en_US
dc.identifier.citationAverina, Stylidis, Brox, Schirmer. NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population. ESC Heart Failure. 2022en_US
dc.identifier.cristinIDFRIDAID 2016466
dc.identifier.doi10.1002/ehf2.13906
dc.identifier.issn2055-5822
dc.identifier.urihttps://hdl.handle.net/10037/25122
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalESC Heart Failure
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleNT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general populationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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