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dc.contributor.advisorRichardsen, Elin
dc.contributor.advisorBusund, Lill-Tove
dc.contributor.authorIngebriktsen, Lise Martine
dc.description.abstractProstate cancer accounts for extensive mortality and is the second most frequent cancer type occurring in men, acknowledged as a severe health problem globally. In Norway, Prostate cancer is the most common form of cancer in men, and around 5.000 patients are diagnosed each year. Using in situ hybridization, we examined the in situ tissue distribution of miR-17-5p and miR-20a-5p in prostate cancer tissue and their potential functions as biomarkers, and assessed their prognostic value from our cohort of 535 prostate cancer patients. We retrospectively evaluated the prognostic impact of marker expression in the clinical outcome Biochemical failure, Clinical failure, and Prostate cancer death by utilizing survival analyses. In addition, we correlated the microRNAs miR-17-5p and miR-20a-5p with the proliferation marker Ki-67. Reducing over-treatment in PCa patients have for many years been an ongoing concern. This controversy underlines the need for more personalized diagnosis and treatment of these patients, whereas miRNAs as biomarkers proposes as promising candidates. miR-17-5p and miR-20a-5p, which are members of the miR-17-92 cluster that are known to act as oncomiRs, may have potential as prognostic biomarkers in prostate cancer, and a possible value in future treatment of prostate cancer.en_US
dc.publisherUiT Norges arktiske universitetno
dc.publisherUiT The Arctic University of Norwayen
dc.rights.holderCopyright 2019 The Author(s)
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)en_US
dc.subjectTranslational Cancer Research groupen_US
dc.titleThe prognostic significance of miR-17-5p and miR-20a-5p in prostate canceren_US
dc.typeMaster thesisen

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Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)