Liver Regeneration in Surgical Animal Models - A Historical Perspective and Clinical Implications
Methods: A systematic review of the English literature published in Medline was undertaken with the search words ‘pig, porcine, dog, canine, liver regeneration, experimental’.
Results: The evolution of the various models tentatively explaining the process of liver regeneration is described.
Conclusions: We conclude by emphasizing the importance of large-animal surgical research on liver regeneration as it offers a more integrated, systemic biological understanding of this complex process. Furthermore, in our opinion, a closer collaboration between the hepatologist, liver surgeon/transplant surgeon and the laboratory scientist may advance clinically relevant research in liver regeneration.