The Association Between Self-Reported Symptoms of Recent Airway Infection and CRP Values in a General Population
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https://hdl.handle.net/10037/25704Dato
2011-11-17Type
Journal articleTidsskriftartikkel
Peer reviewed
Sammendrag
C-reactive protein (CRP) is a much used biomarker for respiratory tract infection;
however, the influence of airway infection on the CRP level in the general population has not been
well described. The study aimed to evaluate the impact of recent symptoms of airway infection on
the CRP level and how the predictive power of other known CRP predictors is influenced by taking
respiratory symptoms into account. A total of 6,325 participants, aged 38–87 years, in the Tromsø
Study, a repeated population-based survey, were examined with questionnaires, measurements of
height and weight, spirometry, and high-sensitivity CRP analyses. The mean CRP value was 2.8-
6 mg/L, and the geometric mean was 1.51 mg/L. Geometric means above 2.0 mg/L were found in
the subgroups with the following characteristics: self-reported COPD, diabetes, recent symptoms of
airway infection, forced expiratory volume in 1 s (FEV1) <80% predicted, body mass index (BMI)
≥30, and subjects treated with inhaled or oral corticosteroids. Among the subjects who reported
recent airway infection, 10.5% had a CRP value of ≥10 mg/L, compared to 3.3% among the
remaining participants. By multivariate analysis, BMI was the strongest independent predictor of the
CRP level, followed by recent airway infection, FEV1% predicted, age, and current smoking. The
study clearly demonstrates that a report of recent symptoms of airway infection strongly predicts the
CRP level in the population. Such symptoms were shared rather equally between subgroups with
increased CRP level, and the risk of being an important confounder in epidemiological studies is
probably low. In the clinical setting, care should be taken when using the CRP level as a guide for
medical prevention of chronic diseases.
Forlag
SpringerSitering
Melbye H, Amundsen K, Brox J, Eggen AE. The Association Between Self-Reported Symptoms of Recent Airway Infection and CRP Values in a General Population. Inflammation. 2012;35(3):1015-1022Metadata
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Copyright 2011 The Author(s)