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dc.contributor.authorSkjerven, Helle
dc.contributor.authorDanielsen, Anders Skyrud
dc.contributor.authorSchlichting, Ellen
dc.contributor.authorSahlberg, Kristine Kleivi
dc.contributor.authorHofvind, Solveig Sand-Hanssen
dc.date.accessioned2022-08-11T08:36:06Z
dc.date.available2022-08-11T08:36:06Z
dc.date.issued2022-04-21
dc.description.abstractIntroduction: The incidence of ductal carcinoma in situ (DCIS) has increased after implementation of mammographic screening. The lesion represents management challenges due to its undetermined growth pattern. We aimed to explore treatment of women aged 48-71 diagnosed with DCIS between 1995 and 2018, by detection mode and histopathological characteristics. Material and methods: Data on surgical treatment and radiation therapy (RT) of 4995 women diagnosed with DCIS were retrieved from the Cancer Registry of Norway. We described the percentage and frequency of breast conserving treatment (BCT) for participants in Breast Screen Norway (screen-detected) and non-participants. We estimated the relative risk (RR) of BCT, using log-binomial regression models. Results: Use of BCT increased from about 40% in 1995 to 85% in 2018. Use of BCT was more common among older than younger women more commonly used for screen-detected versus tumors detected outside the screening program. Nine out of ten women with tumors ≤10mm were treated with BCT, two out of ten with tumors >50mm. RT was given to 89.3% of the women with tumors ≤10 mm, 34.1% of those with tumors classified as van Nuys’ grade 1 and <10mm, and 96.0% of the tumors >50mm. Use of BCT was less common for tumors >50mm compared to <10mm (RR adjusted for age, detection mode, van Nuys’ grade, and localization: 0.26, 95% CI: 0.19-0.36). Conclusion: BCT was increasingly used among women diagnosed with DCIS in Norway during the period from 1995 to 2018, particularly for screen-detected, small lesions with low van Nuys’ grade.en_US
dc.identifier.citationSkjerven H, Danielsen AS, Schlichting E, Sahlberg K, Hofvind S. Treatment of ductal carcinoma in situ: a register-based study of Norwegian women diagnosed between 1995 and 2018. Breast Care. 2022en_US
dc.identifier.cristinIDFRIDAID 2019538
dc.identifier.doi10.1159/000524564
dc.identifier.issn1661-3791
dc.identifier.issn1661-3805
dc.identifier.urihttps://hdl.handle.net/10037/26123
dc.language.isoengen_US
dc.publisherKargeren_US
dc.relation.journalBreast Care
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleTreatment of ductal carcinoma in situ: a register-based study of Norwegian women diagnosed between 1995 and 2018en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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