Association of body mass index with COVID-19 related in-hospital death

Permanent link
https://hdl.handle.net/10037/26273
DOI
https://doi.org/10.1016/j.clnu.2022.01.017
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Date
2022-01-29
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Bouziotis, Jason; Arvanitakis, Marianna; Preiser, Jean-Charles; Abbas, Ali; Abdukahil, Sheryl Ann; Abdulkadir, Nurul Najmee; Abe, Ryuzo; Abel, Laurent; Absil, Lara; Acharya, Subhash; Acker, Andrew; Adachi, Shingo; Adam, Elisabeth; Adrião, Diana; Al Ageel, Saleh; Ahmed, Shakeel; Ain, Quratul; Ainscough, Kate; Aisa, Tharwat; Berdal, Jan-Erik; Dudman, Susanne Gjeruldsen; Dyrhol-Riise, Anne Ma; Skeie, Linda Gail; Heggelund, Lars; Hesstvedt, Liv; Holter, Jan Cato; Jenum, Synne; Johal, Simreen Kaur; Kildal, Anders Benjamin; Bekken, Gry Klouman; Lind, Andreas; Müller, Fredrik; Muller, Karl Erik; Pettersen, Frank O.; Paulsen, Else Quist; Reikvam, Dag Henrik; Holten, Aleksander Rygh; Skogen, Vegard; Stiksrud, Birgitte; Tonby, Kristian
Abstract
Background: Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19.

Methods: The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with competing-risks regression by sex and between the categories of BMI.

Results: Data from 12,137 patients (age 60.0 ± 16.2 years, 59% males, BMI 29.4 ± 6.9 kg/m2 ) of 48 countries were available. By univariate analysis, underweight patients had a higher risk of mortality than the other patients (sub-hazard ratio (SHR) 1.75 [1.44e2.14]). Mortality was lower in normal (SHR 0.69 [0.58e0.85]), overweight (SHR 0.53 [0.43e0.65]) and obese (SHR 0.55 [0.44e0.67]) than in underweight patients. Multivariable analysis (adjusted for age, chronic pulmonary disease, malignant neoplasia, type 2 diabetes) confirmed that in-hospital mortality of underweight patients was higher than overweight patients (females: SHR 0.63 [0.45e0.88] and males: 0.69 [0.51e0.94]).

Conclusion: Even though these findings do not imply changes in the medical care of hospitalized patients, they support the use of BMI category for the stratification of patients enrolled in interventional studies where mortality is recorded as an outcome.

Publisher
Elsevier
Citation
Bouziotis, Arvanitakis M, Preiser J, Abbas A, Abdukahil SA, Abdulkadir NN, Abe R, Abel L, Absil L, Acharya S, Acker A, Adachi S, Adam E, Adrião D, Al Ageel S, Ahmed S, Ain, Ainscough K, Aisa, Berdal JE, Dudman SG, Dyrhol-Riise AM, Skeie Lg, Heggelund L, Hesstvedt L, Holter JC, Jenum S, Johal SK, Kildal AB, Bekken GK, Lind AL, Müller F, Muller KE, Pettersen FO, Paulsen EL, Reikvam DH, Holten AR, Skogen V, Stiksrud B, Tonby K. Association of body mass index with COVID-19 related in-hospital death. Clinical Nutrition. 2022
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