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Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens

Permanent link
https://hdl.handle.net/10037/26464
DOI
https://doi.org/10.3390/v14020427
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Date
2022-02-18
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Prezioso, Carla; Brazzini, Gabriele; Passerini, Sara; Di Fabio, Carlotta; Cosio, Terenzio; Bernardini, Sergio; Campione, Elena; Moens, Ugo; Pietropaolo, Valeria; Ciotti, Marco
Abstract
To date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative agent of Merkel cell carcinoma (MCC) and TSPyV as an etiological agent of Trichodysplasia Spinulosa (TS). In the search for a possible role for cutaneous HPyVs in the development of skin malignant lesions, we investigated the prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in actinic keratosis (AK), a premalignant skin lesion that has the potential to progress towards a squamous cell carcinoma (SCC). One skin lesion and one non-lesion skin from nine affected individuals were analyzed by qualitative PCR. MCPyV was detected in 9 out of 9 lesion biopsies and 6 out of 8 non-lesion biopsies. HPyV6 was detected only in healthy skin, while HPyV7 and TSPyV were not detected in any skin sample. These findings argue against a possible role of cutaneous HPyVs in AK. However, considering the small sample size analyzed, a definitive conclusion cannot be drawn. Longitudinal studies on large cohorts are warranted.
Publisher
MDPI
Citation
Prezioso C, Brazzini G, Passerini S, Di Fabio, Cosio, Bernardini S, Campione, Moens u, Pietropaolo V, Ciotti M. Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens. Viruses. 2022;14(2)
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  • Artikler, rapporter og annet (medisinsk biologi) [1103]
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