dc.contributor.author | Allaoui, Giovanni | |
dc.contributor.author | Rylander, Charlotta | |
dc.contributor.author | Averina, Maria | |
dc.contributor.author | Wilsgaard, Tom | |
dc.contributor.author | Fuskevåg, Ole Martin | |
dc.contributor.author | Berg, Vivian | |
dc.date.accessioned | 2022-09-01T10:36:28Z | |
dc.date.available | 2022-09-01T10:36:28Z | |
dc.date.issued | 2022-02-11 | |
dc.description.abstract | Introduction: Identification of individuals at high risk of developing type 2 diabetes
mellitus (T2DM) is important for early prevention of the disease. Once T2DM is established, it is difficult to treat and is associated with cardiovascular complications and
increased mortality. We aimed to describe pre- and post-diagnostic changes in blood
biomarker concentrations over 30 years in individuals with and without T2DM, and to
determine the predictive potential of pre-diagnostic blood biomarkers.<p>
<p>Methods: This nested case–control study included 234 participants in the Tromsø
Study who gave blood samples at five time points between 1986 and 2016: 130 did not
develop T2DM and were used as controls; 104 developed T2DM after the third time
point and were included as cases. After stratifying by sex, we investigated changes in
pre- and post-diagnostic concentrations of lipids, thyroid hormones, HbA<sub>1c</sub>, glucose
and gamma-glutamyltransferase (GGT) using linear mixed models. We used logistic
regression models and area under the receiver operating characteristic curve (AROC)
to assess associations between blood biomarker concentrations and T2DM, as well as
the predictive ability of blood biomarkers.
<p>Results: Cases and controls experienced different longitudinal changes in lipids, free
T<sub>3</sub>, HbA<sub>1c</sub>, glucose, and GGT. The combination of selected blood biomarker concentrations and basic clinical information displayed excellent (AROC 0.78–0.95) predictive ability at all pre-diagnostic time points. A prediction model that included HDL
(for women), HbA1c, GGT, and basic clinical information demonstrated the strongest
discrimination 7 years before diagnosis (AROC 0.95 for women, 0.85 for men).
<p>Conclusion: There were clear differences in blood biomarker concentrations between
cases and controls throughout the study, and several blood biomarkers were associated with T2DM. Selected blood biomarkers (lipids, HbA<sub>1c</sub>, GGT) in combination with
BMI, physical activity, elevated blood pressure, and family history of T2DM had excellent predictive ability 1–7 years before T2DM diagnosis and acceptable predictive
ability up to 15 years before diagnosis. | en_US |
dc.identifier.citation | Allaoui, Rylander, Averina, Wilsgaard, Fuskevåg, Berg. Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus—The Tromsø study. Endocrinology, Diabetes & Metabolism. 2022;5(2) | en_US |
dc.identifier.cristinID | FRIDAID 2025965 | |
dc.identifier.doi | 10.1002/edm2.325 | |
dc.identifier.issn | 2398-9238 | |
dc.identifier.uri | https://hdl.handle.net/10037/26521 | |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Allaoui, G. (2023). Blood biomarkers and Type 2 Diabetes Mellitus - Repeated measurements of blood biomarkers in Type 2 Diabetes Mellitus cases and controls; longitudinal assessments and associations. (Doctoral thesis). <a href=https://hdl.handle.net/10037/31718>https://hdl.handle.net/10037/31718</a>. | |
dc.relation.journal | Endocrinology, Diabetes & Metabolism | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.title | Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus—The Tromsø study | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |