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dc.contributor.authorSelven, Hallgeir
dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorAndersen, Sigve
dc.contributor.authorRasmussen Busund, Lill-Tove
dc.contributor.authorPedersen, Mona Irene
dc.contributor.authorLombardi, Ana Paola
dc.date.accessioned2022-09-06T10:44:42Z
dc.date.available2022-09-06T10:44:42Z
dc.date.issued2022-04-30
dc.description.abstractIn many types of cancer, microRNAs (miRs) are aberrantly expressed. The aim of this study was to explore the prognostic impact of miR-17-5p and miR-20a-5p in colon cancer. Tumor tissue from 452 stage I-III colon cancer patients was retrospectively collected and tissue microarrays constructed. miR-17-5p and miR-20a-5p expression was evaluated by in situ hybridization and analyzed using digital pathology. Cell line experiments, using HT-29 and CACO-2, were performed to assess the efect of miR-17-5p and miR-20a-5p over expression on viability, invasion and migration. In multivariate analyses, high miR-17-5p expression in tumor (HR= 0.43, CI 0.26–0.71, p < 0.001) and high expression of miR-20a-5p in tumor (HR= 0.60, CI 0.37–0.97, p = 0.037) and stroma (HR= 0.63, CI 0.42–0.95, p = 0.027) remained independent predictors of improved disease-specifc survival. In cell lines, over expression of both miRs resulted in mitigated migration without any signifcant efect on viability or invasion. In conclusion, in stage I-III colon cancer, high expression of both miR-17-5p and miR-20a-5p are independent predictors of favorable prognosis.en_US
dc.identifier.citationSelven, Kilvær, Andersen, Rasmussen Busund, Pedersen, Lombardi. High expression of miR-17-5p and miR-20a-5p predicts favorable disease-specific survival in stage I-III colon cancer. Scientific Reports. 2022en_US
dc.identifier.cristinIDFRIDAID 2025450
dc.identifier.doi10.1038/s41598-022-11090-2
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/26661
dc.language.isoengen_US
dc.publisherNatureen_US
dc.relation.ispartofSelven, H. (2023). Assessing new prognostic biomarkers in resected colon cancer patients. (Doctoral thesis). <a href=https://hdl.handle.net/10037/29356>https://hdl.handle.net/10037/29356</a>.
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleHigh expression of miR-17-5p and miR-20a-5p predicts favorable disease-specific survival in stage I-III colon canceren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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