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dc.contributor.authorvan der Valk, Tom
dc.contributor.authorDehasque, Marianne
dc.contributor.authorChacón-Duque, J. Camilo
dc.contributor.authorOskolkov, Nikolay
dc.contributor.authorVartanyan, Sergey
dc.contributor.authorHeintzman, Peter D.
dc.contributor.authorPečnerová, Patrícia
dc.contributor.authorDíez-del-Molino, David
dc.contributor.authorDalén, Love
dc.date.accessioned2022-11-23T08:53:20Z
dc.date.available2022-11-23T08:53:20Z
dc.date.issued2022-08-01
dc.description.abstractWoolly mammoths had a set of adaptations that enabled them to thrive in the Arctic environment. Many mammoth-specific single nucleotide polymorphisms (SNPs) responsible for unique mammoth traits have been previously identified from ancient genomes. However, a multitude of other genetic variants likely contributed to woolly mammoth evolution. In this study, we sequenced two woolly mammoth genomes and combined these with previously sequenced mammoth and elephant genomes to conduct a survey of mammoth-specific deletions and indels. We find that deletions are highly enriched in non-coding regions, suggesting selection against structural variants that affect protein sequences. Nonetheless, at least 87 woolly mammoth genes contain deletions or indels that modify the coding sequence, including genes involved in skeletal morphology and hair growth. These results suggest that deletions and indels contributed to the unique phenotypic adaptations of the woolly mammoth, and were potentially critical to surviving in its natural environment.en_US
dc.identifier.citationvan der Valk, Dehasque, Chacón-Duque, Oskolkov, Vartanyan, Heintzman, Pečnerová, Díez-del-Molino, Dalén. Evolutionary consequences of genomic deletions and insertions in the woolly mammoth genome. iScience. 2022;25(8)en_US
dc.identifier.cristinIDFRIDAID 2064711
dc.identifier.doi10.1016/j.isci.2022.104826
dc.identifier.issn2589-0042
dc.identifier.urihttps://hdl.handle.net/10037/27489
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journaliScience
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleEvolutionary consequences of genomic deletions and insertions in the woolly mammoth genomeen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)