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dc.contributor.authorChiacchierini, Giulia
dc.contributor.authorNaneix, Fabien
dc.contributor.authorApergis-Schoute, John
dc.contributor.authorMcCutcheon, James Edgar
dc.description.abstractLow-protein diets can impact food intake and appetite, but it is not known if motivation for food is changed. In the present study, we used an operant behavioral task – the progressive ratio test – to assess whether motivation for different foods was affected when rats were maintained on a protein-restricted diet (REST, 5% protein diet) compared to non-restricted control rats (CON, 18% protein). Rats were tested either with nutritionally-balanced pellets (18.7% protein, Experiment 1) or protein-rich pellets (35% protein, Experiment 2) as reinforcers. Protein restriction increased breakpoint for protein-rich pellets, relative to CON rats, whereas no difference in breakpoint for nutritionally-balanced pellets was observed between groups. When given free access to either nutritionally-balanced pellets or protein-rich pellets, REST and CON rats did not differ in their intake. We also tested whether a previous history of protein restriction might affect present motivation for different types of food by assessing breakpoint of previously REST animals that were subsequently put on standard maintenance chow (protein-repleted rats, REPL, Experiment 2). REPL rats did not show increased breakpoint, relative to their initial encounter with protein-rich pellets while they were protein-restricted. This study demonstrates that restriction of dietary protein induces a selective increased motivation for protein-rich food, a behavior that disappears once rats are not in need of protein.en_US
dc.identifier.citationChiacchierini, Naneix, Apergis-Schoute, McCutcheon. Restriction of dietary protein in rats increases progressive-ratio motivation for protein. Physiology and Behavior. 2022;254en_US
dc.identifier.cristinIDFRIDAID 2058409
dc.relation.journalPhysiology and Behavior
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-PEOPLE/631404/Norway/Post-ingestive effects on mesolimbic circuitry/POST-INGEST MESOLIMB/en_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleRestriction of dietary protein in rats increases progressive-ratio motivation for proteinen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)