Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study

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https://hdl.handle.net/10037/27657
DOI
https://doi.org/10.1093/jnci/djac061
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Date
2022-04-19
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Mariosa, Daniela; Smith-Byrne, Karl; Richardson, Tom G.; Ferrari, Pietro; Gunter, Marc J.; Papadimitriou, Nikos; Murphy, Neil; Christakoudi, Sofia; Tsilidis, Konstantinos K.; Riboli, Elio; Muller, David; Purdue, Mark P.; Chanock, Stephen J.; Hung, Rayjean J.; Amos, Christopher I.; O'Mara, Tracy A.; Amiano, Pilar; Pasanisi, Fabrizio; Rodriguez-Barranco, Miguel; Krogh, Vittorio; Tjønneland, Anne; Halkjær, Jytte; Perez-Cornago, Aurora; Chirlaque, María-Dolores; Skeie, Guri; Rylander, Charlotta; Borch, Kristin Benjaminsen; Aune, Dagfinn; Heath, Alicia K.; Ward, Heather A.; Schulze, Matthias; Bonet, Catalina; Weiderpass, Elisabete; Davey Smith, George; Brennan, Paul; Johansson, Mattias
Abstract
It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.
Publisher
Oxford University Press
Citation
Mariosa, Smith-Byrne, Richardson, Ferrari, Gunter, Papadimitriou, Murphy, Christakoudi, Tsilidis, Riboli, Muller, Purdue, Chanock, Hung, Amos, O'Mara, Amiano, Pasanisi, Rodriguez-Barranco, Krogh, Tjønneland, Halkjær, Perez-Cornago, Chirlaque, Skeie, Rylander, Borch, Aune, Heath, Ward, Schulze, Bonet, Weiderpass, Davey Smith, Brennan, Johansson. Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study. Journal of the National Cancer Institute. 2022;114(9):1296-1300
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Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)