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dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorSkogholt, Anne Heidi
dc.contributor.authorUrbarova, Ilona Halva
dc.contributor.authorMjelle, Robin
dc.contributor.authorPaulsen, Erna-Elise
dc.contributor.authorDønnem, Tom
dc.contributor.authorAndersen, Sigve
dc.contributor.authorMarkaki, Maria
dc.contributor.authorRøe, Oluf Dimitri
dc.contributor.authorJohansson, Mikael
dc.contributor.authorJohansson, Mattias
dc.contributor.authorGrønberg, Bjørn Henning
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorSætrom, Pål
dc.description.abstractLung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood at LC diagnosis and evaluated, in pre-diagnostic blood specimens, how long before diagnosis expression changes of such candidate miRNAs could be detected. We identified upregulated candidate miRNAs in plasma specimens from a hospital-based study sample of 128 patients with confirmed LC and 62 individuals with suspected but confirmed negative LC (FalsePos). We then evaluated the expression of candidate miRNAs in pre-diagnostic plasma or serum specimens of 360 future LC cases and 375 matched controls. There were 1663 miRNAs detected in diagnostic specimens, nine of which met our criteria for candidate miRNAs. Higher expression of three candidates, miR-320b, 320c, and 320d, was associated with poor survival, independent of LC stage and subtype. Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within two years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC.en_US
dc.identifier.citationNøst TH, Skogholt AH, Urbarova I, Mjelle R, Paulsen E, Dønnem T, Andersen S, Markaki M, Røe OD, Johansson M, Johansson M, Grønberg BH, Sandanger TM, Sætrom P. Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer. Molecular Oncology. 2022en_US
dc.identifier.cristinIDFRIDAID 2070402
dc.publisherWiley Open Accessen_US
dc.relation.journalMolecular Oncology
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleIncreased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung canceren_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)