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dc.contributor.authorDimou, Niki
dc.contributor.authorOmiyale, Wemimo
dc.contributor.authorBiessy, Carine
dc.contributor.authorViallon, Vivian
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorO'Mara, Tracy A.
dc.contributor.authorAglago, Elom K.
dc.contributor.authorArdanaz, Eva
dc.contributor.authorBergmann, Manuela M.
dc.contributor.authorBondonno, Nicola P.
dc.contributor.authorBraaten, Tonje
dc.contributor.authorColorado-Yohar, Sandra M.
dc.contributor.authorCrous-Bou, Marta
dc.contributor.authorDahm, Christina C.
dc.contributor.authorFortner, Renée T.
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorHarlid, Sophia
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorIdahl, Annika
dc.contributor.authorKvaskoff, Marina
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorOvervad, Kim
dc.contributor.authorPalli, Domenico
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorSimeon, Vittorio
dc.contributor.authorTagliabue, Giovanna
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTruong, Thérése
dc.contributor.authorTumino, Rosario
dc.contributor.authorJohansson, Mattias
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorMurphy, Neil
dc.contributor.authorGunter, Marc J.
dc.contributor.authorLacey, Ben
dc.contributor.authorAllen, Naomi E.
dc.contributor.authorDossus, Laure
dc.date.accessioned2023-01-02T13:56:25Z
dc.date.available2023-01-02T13:56:25Z
dc.date.issued2022-06-16
dc.description.abstractBackground: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.<p> <p>Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined.<p> <p>Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91–1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer.<p> <p>Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer.<p> <p>Impact: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.en_US
dc.identifier.citationDimou, Omiyale, Biessy, Viallon, Kaaks, O'Mara, Aglago, Ardanaz, Bergmann, Bondonno, Braaten, Colorado-Yohar, Crous-Bou, Dahm, Fortner, Gram, Harlid, Heath, Idahl, Kvaskoff, Nøst, Overvad, Palli, Perez-Cornago, Sacerdote, Sánchez, Schulze, Severi, Simeon, Tagliabue, Tjønneland, Truong, Tumino, Johansson, Weiderpass, Murphy, Gunter, Lacey, Allen, Dossus. Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses. Cancer Epidemiology, Biomarkers and Prevention. 2022;31(9):1839-1848en_US
dc.identifier.cristinIDFRIDAID 2071168
dc.identifier.doi10.1158/1055-9965.EPI-21-1176
dc.identifier.issn1055-9965
dc.identifier.issn1538-7755
dc.identifier.urihttps://hdl.handle.net/10037/27979
dc.language.isoengen_US
dc.publisherAmerican Association for Cancer Researchen_US
dc.relation.journalCancer Epidemiology, Biomarkers and Prevention
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleCigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analysesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)