Gastrointestinal tract (GI) cancers are among the most common types of cancers worldwide. In particular, colorectal cancer (CRC) is the most lethal in terms of number of incidences and mortality (third most common cause of cancer and the second common cause of cancer-related deaths). Colonoscopy is the gold standard for screening patients for CRC. During the colonoscopy, gastroenterologists examine ...

This thesis introduces the MAR databases as marine-specific resources in the genomic landscape. Paper 1 describes the curation effort and development leading to the MAR databases being created. It results in the highly valued reference database MarRef, the broader MarDB, and the marine gene catalog MarCat. Definition of a marine environment, the curation process, and the Marine Metagenomics Portal ...

The non-transient plasma that is closest to Earth is found in the ionosphere at altitudes above approximately 60 km. It is observed either by ground-based, in-situ, or space-borne instrumentation and utilized to study and determine plasma phenomena and dynamics and the near-Earth space. Through active modification experiments, transmitting high-power, high-frequency radio waves into the ionospheric ...

Every year, millions of scientific images are acquired in order to study the auroral phenomena. The accumulated data contain a vast amount of untapped information that can be used in auroral science. Yet, auroral research has traditionally been focused on case studies, where one or a few auroral events have been investigated and explained in detail. Consequently, theories have often been developed ...

Climate change affects the Arctic to a greater extent than the global average, causing rapid sea-ice loss and changes in the inflow of warm Atlantic water in the Arctic. Arctic sediments host vast amounts of greenhouse gases in the form of gas hydrates (ice-like cages that trap gas within), that can be released to the seafloor if temperature increases and/or pressure decreases. Climate projections ...

Our understanding of how antimicrobial resistance enzymes evolve to expand their substrate spectrum is limited. OXA-48, an enzyme able to catalyse the hydrolysis of β-lactam drugs, has become one of the most successfully disseminating β-lactamases. Although OXA-48 hydrolyses penicillins with high efficiency, its activity towards oxyimino cephalosporins, such as ceftazidime, is limited. Thus, ceftazidime ...

Fields like medical diagnostics, urban and industrial environmental monitoring or basic microbiological research greatly benefit from advances in chemical and biological sensing. These applications require rapid sample analysis, reduced needs for sample handling, or good sensor network. Such demands can be met with miniaturised sensors utilising methods which secure sufficient sensitivity and ...

The exhaust of particles and heat in the boundary of contemporary magnetic confinement experiments remains to this day a major obstacle on the road to commercially viable fusion energy production. It is recognized, that coherent structures of hot and dense plasma, called blobs or filaments, are the dominant mechanism for cross-field particle transport. These filaments are created by plasma turbulence ...

A complete representation of the Arctic cryosphere has historically been restricted by its remoteness, large extent, and restrictions in measurement methods and equipment. Here, remote sensing of snow-cover is a central method to improve the current knowledge of the Earth's ecosystem, and hence a critical component in cryospheric models. The use of drone-borne radar systems has seen considerable ...