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dc.contributor.authorPasserini, Sara
dc.contributor.authorPrezioso, Carla
dc.contributor.authorProta, Annalisa
dc.contributor.authorBabini, Giulia
dc.contributor.authorCoppola, Luigi
dc.contributor.authorLodi, Alessandra
dc.contributor.authorEpifani, Anna Chiara
dc.contributor.authorSarmati, Loredana
dc.contributor.authorAndreoni, Massimo
dc.contributor.authorMoens, Ugo
dc.contributor.authorPietropaolo, Valeria
dc.contributor.authorCiotti, Marco
dc.date.accessioned2023-01-10T08:07:43Z
dc.date.available2023-01-10T08:07:43Z
dc.date.issued2022-11-17
dc.description.abstractSince it was clearly established that HIV/AIDS predisposes to the infection, persistence or reactivation of latent viruses, the prevalence of human polyomaviruses (HPyVs) among HIV-1-infected patients and a possible correlation between HPyVs and HIV sero-status were investigated. PCR was performed to detect and quantify JCPyV, BKPyV, MCPyV, HPyV6, HPyV7 and QPyV DNA in the urine and plasma samples of 103 HIV-1-infected patients. Subsequently, NCCR, VP1 and MCPyV LT sequences were examined. In addition, for MCPyV, the expression of transcripts for the LT gene was investigated. JCPyV, BKPyV and MCPyV’s presence was reported, whereas HPyV6, HPyV7 and QPyV were not detected in any sample. Co-infection patterns of JCPyV, BKPyV and MCPyV were found. Archetype-like NCCRs were observed with some point mutations in plasma samples positive for JCPyV and BKPyV. The VP1 region was found to be highly conserved among these subjects. LT did not show mutations causing stop codons, and LT transcripts were expressed in MCPyV positive samples. A significant correlation between HPyVs’ detection and a low level of CD4+ was reported. In conclusion, HPyV6, HPyV7 and QPyV seem to not have a clinical relevance in HIV-1 patients, whereas further studies are warranted to define the clinical importance of JCPyV, BKPyV and MCPyV DNA detection in these subjects.en_US
dc.identifier.citationPasserini, Prezioso, Prota, Babini, Coppola, Lodi, Epifani, Sarmati, Andreoni, Moens, Pietropaolo, Ciotti. Detection Analysis and Study of Genomic Region Variability of JCPyV, BKPyV, MCPyV, HPyV6, HPyV7 and QPyV in the Urine and Plasma of HIV-1-Infected Patients. Viruses. 2022;14(11)en_US
dc.identifier.cristinIDFRIDAID 2093104
dc.identifier.doi10.3390/v14112544
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/10037/28102
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalViruses
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleDetection Analysis and Study of Genomic Region Variability of JCPyV, BKPyV, MCPyV, HPyV6, HPyV7 and QPyV in the Urine and Plasma of HIV-1-Infected Patientsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
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