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dc.contributor.authorSundberg, Lotta-Riina
dc.contributor.authorRantanen, Noora
dc.contributor.authorde Freitas Almeida, Gabriel Magno
dc.description.abstractPathogenic bacteria are attracted toward mucosa, as it is their way of entry into the body. However, we know surprisingly little about the phage-bacterium interactions in the mucosal environment. Here, we explored the effect of the mucosal environment on growth characteristics and phage-bacterium interactions in Streptococcus mutans, a causative agent of dental caries. We found that although mucin supplementation increased bacterial growth and survival, it decreased S. mutans biofilm formation. More importantly, the presence of mucin had a significant effect on S. mutans phage susceptibility. In two experiments done in Brain Heart Infusion Broth, phage M102 replication was detected only with 0.2% mucin supplementation. In 0.1 × Tryptic Soy Broth, 0.5% mucin supplementation led to a 4-log increase in phage titers compared with the control. These results suggest that the mucosal environment can have a major role in the growth, phage sensitivity, and phage resistance of S. mutans, and underline the importance of understanding the effect of mucosal environment on phage-bacterium interactions.en_US
dc.identifier.citationSundberg, Rantanen, de Freitas Almeida. Mucosal Environment Induces Phage Susceptibility in Streptococcus mutans. PHAGE: Therapy, Applications, and Research. 2022;3(3):128-135en_US
dc.identifier.cristinIDFRIDAID 2082490
dc.publisherMary Ann Lieberten_US
dc.relation.journalPHAGE: Therapy, Applications, and Research
dc.relation.projectIDUiT Norges arktiske universitet: 2520855en_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleMucosal Environment Induces Phage Susceptibility in Streptococcus mutansen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)