dc.contributor.author | Jia, Jingyue | |
dc.contributor.author | Wang, Fulong | |
dc.contributor.author | Bhujabal, Zambarlal Babanrao | |
dc.contributor.author | Peters, Ryan | |
dc.contributor.author | Mudd, Michal | |
dc.contributor.author | Duque, Thabata | |
dc.contributor.author | Allers, Lee | |
dc.contributor.author | Javed, Ruheena | |
dc.contributor.author | Salemi, Michelle | |
dc.contributor.author | Behrends, Christian | |
dc.contributor.author | Phinney, Brett | |
dc.contributor.author | Johansen, Terje | |
dc.contributor.author | Deretic, Vojo | |
dc.date.accessioned | 2023-03-15T10:08:12Z | |
dc.date.available | 2023-03-15T10:08:12Z | |
dc.date.issued | 2022 | |
dc.description.abstract | We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG)
formation and that the process termed membrane atg8ylation coordinates SG formation
with mTOR inactivation during lysosomal stress. SGs were induced by lysosomedamaging agents including SARS-CoV-2ORF3a, Mycobacterium tuberculosis, and
proteopathic tau. During damage, mammalian ATG8s directly interacted with the core
SG proteins NUFIP2 and G3BP1. Atg8ylation was needed for their recruitment to
damaged lysosomes independently of SG condensates whereupon NUFIP2 contributed
to mTOR inactivation via the Ragulator-RagA/B complex. Thus, cells employ membrane
atg8ylation to control and coordinate SG and mTOR responses to lysosomal damage. | en_US |
dc.identifier.citation | Jia, Wang, Bhujabal, Peters, Mudd, Duque, Allers, Javed, Salemi, Behrends, Phinney, Johansen, Deretic. Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage. Journal of Cell Biology. 2022;221(11) | en_US |
dc.identifier.cristinID | FRIDAID 2078340 | |
dc.identifier.doi | 10.1083/jcb.202207091 | |
dc.identifier.issn | 0021-9525 | |
dc.identifier.issn | 1540-8140 | |
dc.identifier.uri | https://hdl.handle.net/10037/28759 | |
dc.language.iso | eng | en_US |
dc.publisher | Rockefeller University Press | en_US |
dc.relation.journal | Journal of Cell Biology | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage | en_US |
dc.type.version | acceptedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |