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dc.contributor.authorCharles, Dolley
dc.contributor.authorBerg, Vivian
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorBergdahl, Ingvar A.
dc.contributor.authorHuber, Sandra
dc.contributor.authorAyotte, Pierre
dc.contributor.authorAverina, Maria
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorRylander, Karin Charlotta Maria
dc.date.accessioned2023-04-12T07:35:16Z
dc.date.available2023-04-12T07:35:16Z
dc.date.issued2023-03-05
dc.description.abstract<p><i>Background:</i> Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between PBDEs and T2DM. No longitudinal studies have assessed associations between repeated measurements of PBDE and T2DM in the same individuals and compared time trends of PBDEs in T2DM cases and controls. <p><i>Objectives:</i> To investigate associations between pre- and post-diagnostic measurements of PBDEs and T2DM and to compare time trends of PBDEs in T2DM cases and controls. <p><i>Methods:</i> Questionnaire data and serum samples from participants in the Tromsø Study were used to conduct a longitudinal nested case-control study among 116 T2DM cases and 139 controls. All included study participants had three pre-diagnostic blood samples (collected before T2DM diagnosis in cases), and up to two post-diagnostic samples after T2DM diagnosis. We used logistic regression models to investigate pre- and post-diagnostic associations between PBDEs and T2DM, and linear mixed-effect models to assess time trends of PBDEs in T2DM cases and controls. <p><i>Results:</i> We observed no substantial pre- or post-diagnostic associations between any of the PBDEs and T2DM, except for BDE-154 at one of the post-diagnostic time-points (OR = 1.65, 95% CI: 1.00, 2.71). The overall time trends of PBDE concentrations were similar for cases and controls. <p><i>Discussion:</i> The study did not support PBDEs increasing the odds of T2DM, prior to or after T2DM diagnosis. T2DM status did not influence the time trends of PBDE concentrations.en_US
dc.identifier.citationCharles, Berg, Nøst, Wilsgaard, Bergdahl, Huber, Ayotte, Averina, Sandanger, Rylander. Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis. International Journal of Hygiene and Environmental Health. 2023;249en_US
dc.identifier.cristinIDFRIDAID 2137261
dc.identifier.doi10.1016/j.ijheh.2023.114148
dc.identifier.issn1438-4639
dc.identifier.issn1618-131X
dc.identifier.urihttps://hdl.handle.net/10037/28951
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalInternational Journal of Hygiene and Environmental Health
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.subjectThe Tromsø Studyen_US
dc.subjectTromsøundersøkelsenen_US
dc.titlePolybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)