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dc.contributor.authorJensen, Ingvill
dc.date.accessioned2023-08-25T08:22:11Z
dc.date.available2023-08-25T08:22:11Z
dc.date.issued2023
dc.description.abstractEvolutionarily conserved, “natural” (n)IgM is broadly reactive to both self and foreign antigens. Its selective deficiency leads to increases in autoimmune diseases and infections. In mice, nIgM is secreted independent of microbial exposure to bone marrow (BM) and spleen B-1 cell–derived plasma cells (B-1PC), generating the majority of nIgM, or by B-1 cells that remain non-terminally differentiated (B-1sec). Thus, it has been assumed that the nIgM repertoire is broadly reflective of the repertoire of body cavity B-1 cells. Studies here reveal, however, that B-1PC generate a distinct, oligoclonal nIgM repertoire, characterized by short CDR3 variable immunoglobulin heavy chain regions, 7–8 amino acids in length, some public, many arising from convergent rearrangements, while specificities previously associated with nIgM were generated by a population of IgM-secreting B-1 (B-1sec). BM, but not spleen B-1PC, or B-1sec also required the presence of TCRαβ CD4 T cells for their development from fetal precursors. Together, the studies identify important previously unknown characteristics of the nIgM pool.en_US
dc.identifier.citationJensen. B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM. Journal of Experimental Medicine (JEM). 2023en_US
dc.identifier.cristinIDFRIDAID 2159186
dc.identifier.doi10.1084/jem.20220195
dc.identifier.issn0022-1007
dc.identifier.issn1540-9538
dc.identifier.urihttps://hdl.handle.net/10037/30409
dc.language.isoengen_US
dc.publisherRockefeller University Pressen_US
dc.relation.journalJournal of Experimental Medicine (JEM)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)en_US
dc.titleB-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgMen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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