dc.contributor.author | Haugen, Mads | |
dc.contributor.author | von der Lippe Gythfeldt, Hedda | |
dc.contributor.author | Egeland, Eivind Valen | |
dc.contributor.author | Svartdal Normann, Lisa | |
dc.contributor.author | Pandya, Abhilash D. | |
dc.contributor.author | Vedin, Lise-Lotte | |
dc.contributor.author | Juell, Siri | |
dc.contributor.author | Tenstad, Ellen | |
dc.contributor.author | Øy, Geir Frode | |
dc.contributor.author | Kristian, Alexandr | |
dc.contributor.author | Marangoni, Elisabetta | |
dc.contributor.author | Sørlie, Therese | |
dc.contributor.author | Steffensen, Knut Rune | |
dc.contributor.author | Mælandsmo, Gunhild Mari | |
dc.contributor.author | Engebråten, Olav | |
dc.date.accessioned | 2023-09-11T08:21:48Z | |
dc.date.available | 2023-09-11T08:21:48Z | |
dc.date.issued | 2023-06-21 | |
dc.description.abstract | Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent a therapeutic opportunity in cancers lacking targeted therapies, such as triple-negative breast cancer. In this study, we investigated the impact of LXR agonists alone and in combination with carboplatin in preclinical models of breast cancer. In vitro experiments revealed a dose-dependent decrease in tumor cell proliferation in estrogen receptor-positive breast cancer cells, whereas LXR activation in vivo resulted in an increased growth inhibitory effect in a basal-like breast cancer model (in combination with carboplatin). Functional proteomic analysis identified differences in protein expression between responding and nonresponding models related to Akt activity, cell-cycle progression, and DNA repair. Furthermore, pathway analysis suggested that the LXR agonist in combination with carboplatin inhibits the activity of targets of E2F transcription factors and affects cholesterol homeostasis in basal-like breast cancer. | en_US |
dc.identifier.citation | Haugen, von der Lippe Gythfeldt, Egeland, Svartdal Normann, Pandya, Vedin, Juell, Tenstad, Øy, Kristian, Marangoni, Sørlie, Steffensen, Mælandsmo, Engebråten. Liver X receptors induce antiproliferative effects in basal-like breast cancer. Molecular Oncology. 2023 | en_US |
dc.identifier.cristinID | FRIDAID 2172407 | |
dc.identifier.doi | 10.1002/1878-0261.13476 | |
dc.identifier.issn | 1574-7891 | |
dc.identifier.issn | 1878-0261 | |
dc.identifier.uri | https://hdl.handle.net/10037/30877 | |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | Molecular Oncology | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Liver X receptors induce antiproliferative effects in basal-like breast cancer | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |