Vis enkel innførsel

dc.contributor.authorHaugen, Mads
dc.contributor.authorvon der Lippe Gythfeldt, Hedda
dc.contributor.authorEgeland, Eivind Valen
dc.contributor.authorSvartdal Normann, Lisa
dc.contributor.authorPandya, Abhilash D.
dc.contributor.authorVedin, Lise-Lotte
dc.contributor.authorJuell, Siri
dc.contributor.authorTenstad, Ellen
dc.contributor.authorØy, Geir Frode
dc.contributor.authorKristian, Alexandr
dc.contributor.authorMarangoni, Elisabetta
dc.contributor.authorSørlie, Therese
dc.contributor.authorSteffensen, Knut Rune
dc.contributor.authorMælandsmo, Gunhild Mari
dc.contributor.authorEngebråten, Olav
dc.date.accessioned2023-09-11T08:21:48Z
dc.date.available2023-09-11T08:21:48Z
dc.date.issued2023-06-21
dc.description.abstractLiver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent a therapeutic opportunity in cancers lacking targeted therapies, such as triple-negative breast cancer. In this study, we investigated the impact of LXR agonists alone and in combination with carboplatin in preclinical models of breast cancer. In vitro experiments revealed a dose-dependent decrease in tumor cell proliferation in estrogen receptor-positive breast cancer cells, whereas LXR activation in vivo resulted in an increased growth inhibitory effect in a basal-like breast cancer model (in combination with carboplatin). Functional proteomic analysis identified differences in protein expression between responding and nonresponding models related to Akt activity, cell-cycle progression, and DNA repair. Furthermore, pathway analysis suggested that the LXR agonist in combination with carboplatin inhibits the activity of targets of E2F transcription factors and affects cholesterol homeostasis in basal-like breast cancer.en_US
dc.identifier.citationHaugen, von der Lippe Gythfeldt, Egeland, Svartdal Normann, Pandya, Vedin, Juell, Tenstad, Øy, Kristian, Marangoni, Sørlie, Steffensen, Mælandsmo, Engebråten. Liver X receptors induce antiproliferative effects in basal-like breast cancer. Molecular Oncology. 2023en_US
dc.identifier.cristinIDFRIDAID 2172407
dc.identifier.doi10.1002/1878-0261.13476
dc.identifier.issn1574-7891
dc.identifier.issn1878-0261
dc.identifier.urihttps://hdl.handle.net/10037/30877
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalMolecular Oncology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleLiver X receptors induce antiproliferative effects in basal-like breast canceren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)