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dc.contributor.authorTimón, Santiago
dc.contributor.authorRincón, Mariano
dc.contributor.authorMartínez-Tomás, Rafael
dc.contributor.authorKirsebom, Bjørn-Eivind Seljelid
dc.contributor.authorFladby, Tormod
dc.date.accessioned2023-11-14T10:04:30Z
dc.date.available2023-11-14T10:04:30Z
dc.date.issued2023-09-20
dc.description.abstractDementia disease research encompasses diverse data modalities, including advanced imaging, deep phenotyping, and multi-omics analysis. However, integrating these disparate data sources has historically posed a significant challenge, obstructing the unification and comprehensive analysis of collected information. In recent years, knowledge graphs have emerged as a powerful tool to address such integration issues by enabling the consolidation of heterogeneous data sources into a structured, interconnected network of knowledge. In this context, we introduce DemKG, an open-source framework designed to facilitate the construction of a knowledge graph integrating dementia research data, comprising three core components: a KG-builder that integrates diverse domain ontologies and data annotations, an extensions ontology providing necessary terms tailored for dementia research, and a versatile transformation module for incorporating study data. In contrast with other current solutions, our framework provides a stable foundation by leveraging established ontologies and community standards and simplifies study data integration while delivering solid ontology design patterns, broadening its usability. Furthermore, the modular approach of its components enhances flexibility and scalability. We showcase how DemKG might aid and improve multi-modal data investigations through a series of proof-of-concept scenarios focused on relevant Alzheimer’s disease biomarkers.en_US
dc.identifier.citationTimón S, Rincón, Martínez-Tomás, Kirsebom, Fladby. A Knowledge Graph Framework for Dementia Research Data. Applied Sciences. 2023;13(18):1-23en_US
dc.identifier.cristinIDFRIDAID 2188011
dc.identifier.doi10.3390/app131810497
dc.identifier.issn2076-3417
dc.identifier.urihttps://hdl.handle.net/10037/31760
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalApplied Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleA Knowledge Graph Framework for Dementia Research Dataen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)