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dc.contributor.authorBokil, Ansooya Avinash
dc.contributor.authorBørkja, Mathieu
dc.contributor.authorWolowczyk, Camilla Izabel
dc.contributor.authorLamsal, Apsana
dc.contributor.authorPrestvik, Wenche S.
dc.contributor.authorNonstad, Unni
dc.contributor.authorPettersen, Kristine
dc.contributor.authorAndersen, Sonja Benedikte
dc.contributor.authorBofin, Anna M.
dc.contributor.authorBjørkøy, Geir
dc.contributor.authorHak, Sjoerd
dc.contributor.authorGiambelluca, Miriam Soledad
dc.description.abstractBackground: Myeloid cells play an essential role in cancer metastasis. The phenotypic diversity of these cells during cancer development has attracted great interest; however, their functional heterogeneity and plasticity have limited their role as prognostic markers and therapeutic targets. <p><p>Methods: To identify markers associated with myeloid cells in metastatic tumours, we compared transcriptomic data from immune cells sorted from metastatic and non-metastatic mammary tumours grown in BALB/cJ mice. To assess the translational relevance of our in vivo findings, we assessed human breast cancer biopsies and evaluated the association between arginase 1 protein expression in breast cancer tissues with tumour characteristics and patient outcomes. <p>Results: Among the differentially expressed genes, arginase 1 (ARG1) showed a unique expression pattern in tumour-infiltrating myeloid cells that correlated with the metastatic capacity of the tumour. Even though ARG1-positive cells were found almost exclusively inside the metastatic tumour, ARG1 protein was also present in the plasma. In human breast cancer biopsies, the presence of ARG1-positive cells was strongly correlated with high-grade proliferating tumours, poor prognosis, and low survival. <p>Conclusion: Our findings highlight the potential use of ARG1-positive myeloid cells as an independent prognostic marker to evaluate the risk of metastasis in breast cancer patients.en_US
dc.identifier.citationBokil AA, Børkja MB, Wolowczyk CI, Lamsal A, Prestvik WS, Nonstad U, Pettersen K, Andersen SB, Bofin A M, Bjørkøy GB, Hak S, Giambelluca M. Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours. Cancer Cell International. 2023;23en_US
dc.identifier.cristinIDFRIDAID 2198711
dc.relation.journalCancer Cell International
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleDiscovery of a new marker to identify myeloid cells associated with metastatic breast tumoursen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)