Forfatter
Magnussen, Christina;
Ojeda, Francisco M.;
Leong, Darryl P.;
Alegre-Diaz, Jesus;
Amouyel, Philippe;
Aviles-Santa, Larissa;
De Bacquer, Dirk;
Ballantyne, Christie M.;
Bernabé-Ortiz, Antonio;
Bobak, Martin;
Brenner, Hermann;
Carrillo-Larco, Rodrigo M.;
De Lemos, James;
Dobson, Annette;
Dörr, Marcus;
Donfrancesco, Chiara;
Drygas, Wojciech;
Dullaart, Robin P.;
Engström, Gunnar;
Ferrario, Marco M.;
Ferrières, Jean;
De Gaetano, Giovanni;
Goldbourt, Uri;
Gonzalez, Clicerio;
Grassi, Guido;
Hodge, Allison M.;
Hveem, Kristian;
Iacoviello, Licia;
Ikram, M. Kamran;
Irazola, Vilma;
Jobe, Modou;
Jousilahti, Pekka;
Kaleebu, Pontiano;
Kavousi, Maryam;
Kee, Frank;
Khalili, Davood;
Koenig, Wolfgang;
Kontsevaya, Anna;
Kuulasmaa, Kari;
Lackner, Karl J.;
Leistner, David M.;
Lind, Lars;
Linneberg, Allan;
Lorenz, Thiess;
Lyngbakken, Magnus Nakrem;
Malekzadeh, Reza;
Malyutina, Sofia;
Mathiesen, Ellisiv B.;
Melander, Olle;
Metspalu, Andres;
Miranda, J. Jaime;
Moitry, Marie;
Mugisha, Joseph;
Nalini, Mahdi;
Nambi, Vijay;
Ninomiya, Toshiharu;
Oppermann, Karen;
D'Orsi, Eleonora;
Pająk, Andrzej;
Palmieri, Luigi;
Panagiotakos, Demosthenes;
Perianayagam, Arokiasamy;
Peters, Annette;
Poustchi, Hossein;
Prentice, Andrew M.;
Prescott, Eva;
Risérus, Ulf;
Salomaa, Veikko;
Sans, Susana;
Sakata, Satoko;
Schöttker, Ben;
Schutte, Aletta E.;
Sepanlou, Sadaf G.;
Sharma, Sanjib Kumar;
Shaw, Jonathan E.;
Simons, Leon A.;
Söderberg, Stefan;
Tamosiunas, Abdonas;
Thorand, Barbara;
Tunstall-Pedoe, Hugh;
Twerenbold, Raphael;
Vanuzzo, Diego;
Veronesi, Giovanni;
Waibel, Julia;
Wannamethee, S. Goya;
Watanabe, Masafumi;
Wild, Philipp S.;
Yao, Yao;
Zeng, Yi;
Ziegler, Andreas;
Blankenberg, Stefan
Sammendrag
BACKGROUND - Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.
METHODS - We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.
RESULTS - Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).
CONCLUSIONS - Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825. opens in new tab.)
Forlag
Massachusetts Medical Society
Sitering
Magnussen, Ojeda, Leong, Alegre-Diaz, Amouyel, Aviles-Santa, De Bacquer, Ballantyne, Bernabé-Ortiz, Bobak, Brenner, Carrillo-Larco, De Lemos, Dobson, Dörr, Donfrancesco, Drygas, Dullaart, Engström, Ferrario, Ferrières, De Gaetano, Goldbourt, Gonzalez, Grassi, Hodge, Hveem, Iacoviello, Ikram, Irazola, Jobe, Jousilahti, Kaleebu, Kavousi, Kee, Khalili, Koenig, Kontsevaya, Kuulasmaa, Lackner, Leistner, Lind, Linneberg, Lorenz, Lyngbakken, Malekzadeh, Malyutina, Mathiesen, Melander, Metspalu, Miranda, Moitry, Mugisha, Nalini, Nambi, Ninomiya, Oppermann, D'Orsi, Pająk, Palmieri, Panagiotakos, Perianayagam, Peters, Poustchi, Prentice, Prescott, Risérus, Salomaa, Sans, Sakata, Schöttker, Schutte, Sepanlou, Sharma, Shaw, Simons, Söderberg, Tamosiunas, Thorand, Tunstall-Pedoe, Twerenbold, Vanuzzo, Veronesi, Waibel, Wannamethee, Watanabe, Wild, Yao, Zeng, Ziegler, Blankenberg. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.. New England Journal of Medicine. 2023;389(14):1273-1285
English
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