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dc.contributor.authorMagnussen, Christina
dc.contributor.authorOjeda, Francisco M.
dc.contributor.authorLeong, Darryl P.
dc.contributor.authorAlegre-Diaz, Jesus
dc.contributor.authorAmouyel, Philippe
dc.contributor.authorAviles-Santa, Larissa
dc.contributor.authorDe Bacquer, Dirk
dc.contributor.authorBallantyne, Christie M.
dc.contributor.authorBernabé-Ortiz, Antonio
dc.contributor.authorBobak, Martin
dc.contributor.authorBrenner, Hermann
dc.contributor.authorCarrillo-Larco, Rodrigo M.
dc.contributor.authorDe Lemos, James
dc.contributor.authorDobson, Annette
dc.contributor.authorDörr, Marcus
dc.contributor.authorDonfrancesco, Chiara
dc.contributor.authorDrygas, Wojciech
dc.contributor.authorDullaart, Robin P.
dc.contributor.authorEngström, Gunnar
dc.contributor.authorFerrario, Marco M.
dc.contributor.authorFerrières, Jean
dc.contributor.authorDe Gaetano, Giovanni
dc.contributor.authorGoldbourt, Uri
dc.contributor.authorGonzalez, Clicerio
dc.contributor.authorGrassi, Guido
dc.contributor.authorHodge, Allison M.
dc.contributor.authorHveem, Kristian
dc.contributor.authorIacoviello, Licia
dc.contributor.authorIkram, M. Kamran
dc.contributor.authorIrazola, Vilma
dc.contributor.authorJobe, Modou
dc.contributor.authorJousilahti, Pekka
dc.contributor.authorKaleebu, Pontiano
dc.contributor.authorKavousi, Maryam
dc.contributor.authorKee, Frank
dc.contributor.authorKhalili, Davood
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorKontsevaya, Anna
dc.contributor.authorKuulasmaa, Kari
dc.contributor.authorLackner, Karl J.
dc.contributor.authorLeistner, David M.
dc.contributor.authorLind, Lars
dc.contributor.authorLinneberg, Allan
dc.contributor.authorLorenz, Thiess
dc.contributor.authorLyngbakken, Magnus Nakrem
dc.contributor.authorMalekzadeh, Reza
dc.contributor.authorMalyutina, Sofia
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorMelander, Olle
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMiranda, J. Jaime
dc.contributor.authorMoitry, Marie
dc.contributor.authorMugisha, Joseph
dc.contributor.authorNalini, Mahdi
dc.contributor.authorNambi, Vijay
dc.contributor.authorNinomiya, Toshiharu
dc.contributor.authorOppermann, Karen
dc.contributor.authorD'Orsi, Eleonora
dc.contributor.authorPająk, Andrzej
dc.contributor.authorPalmieri, Luigi
dc.contributor.authorPanagiotakos, Demosthenes
dc.contributor.authorPerianayagam, Arokiasamy
dc.contributor.authorPeters, Annette
dc.contributor.authorPoustchi, Hossein
dc.contributor.authorPrentice, Andrew M.
dc.contributor.authorPrescott, Eva
dc.contributor.authorRisérus, Ulf
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSans, Susana
dc.contributor.authorSakata, Satoko
dc.contributor.authorSchöttker, Ben
dc.contributor.authorSchutte, Aletta E.
dc.contributor.authorSepanlou, Sadaf G.
dc.contributor.authorSharma, Sanjib Kumar
dc.contributor.authorShaw, Jonathan E.
dc.contributor.authorSimons, Leon A.
dc.contributor.authorSöderberg, Stefan
dc.contributor.authorTamosiunas, Abdonas
dc.contributor.authorThorand, Barbara
dc.contributor.authorTunstall-Pedoe, Hugh
dc.contributor.authorTwerenbold, Raphael
dc.contributor.authorVanuzzo, Diego
dc.contributor.authorVeronesi, Giovanni
dc.contributor.authorWaibel, Julia
dc.contributor.authorWannamethee, S. Goya
dc.contributor.authorWatanabe, Masafumi
dc.contributor.authorWild, Philipp S.
dc.contributor.authorYao, Yao
dc.contributor.authorZeng, Yi
dc.contributor.authorZiegler, Andreas
dc.contributor.authorBlankenberg, Stefan
dc.date.accessioned2024-01-22T10:03:10Z
dc.date.available2024-01-22T10:03:10Z
dc.date.issued2023
dc.description.abstractBACKGROUND - Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.<p> <p>METHODS - We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.<p> <p>RESULTS - Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).<p> <p>CONCLUSIONS - Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825. opens in new tab.)en_US
dc.identifier.citationMagnussen, Ojeda, Leong, Alegre-Diaz, Amouyel, Aviles-Santa, De Bacquer, Ballantyne, Bernabé-Ortiz, Bobak, Brenner, Carrillo-Larco, De Lemos, Dobson, Dörr, Donfrancesco, Drygas, Dullaart, Engström, Ferrario, Ferrières, De Gaetano, Goldbourt, Gonzalez, Grassi, Hodge, Hveem, Iacoviello, Ikram, Irazola, Jobe, Jousilahti, Kaleebu, Kavousi, Kee, Khalili, Koenig, Kontsevaya, Kuulasmaa, Lackner, Leistner, Lind, Linneberg, Lorenz, Lyngbakken, Malekzadeh, Malyutina, Mathiesen, Melander, Metspalu, Miranda, Moitry, Mugisha, Nalini, Nambi, Ninomiya, Oppermann, D'Orsi, Pająk, Palmieri, Panagiotakos, Perianayagam, Peters, Poustchi, Prentice, Prescott, Risérus, Salomaa, Sans, Sakata, Schöttker, Schutte, Sepanlou, Sharma, Shaw, Simons, Söderberg, Tamosiunas, Thorand, Tunstall-Pedoe, Twerenbold, Vanuzzo, Veronesi, Waibel, Wannamethee, Watanabe, Wild, Yao, Zeng, Ziegler, Blankenberg. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.. New England Journal of Medicine. 2023;389(14):1273-1285en_US
dc.identifier.cristinIDFRIDAID 2216132
dc.identifier.doi10.1056/NEJMoa2206916
dc.identifier.issn0028-4793
dc.identifier.issn1533-4406
dc.identifier.urihttps://hdl.handle.net/10037/32657
dc.language.isoengen_US
dc.publisherMassachusetts Medical Societyen_US
dc.relation.journalNew England Journal of Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titleGlobal Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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