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dc.contributor.authorNieder, Carsten
dc.contributor.authorAndratschke, Nicolaus H.
dc.contributor.authorGrosu, Anca L.
dc.date.accessioned2024-01-23T14:33:54Z
dc.date.available2024-01-23T14:33:54Z
dc.date.issued2023-03-27
dc.description.abstractWhole-brain radiation therapy (WBRT) has commonly been prescribed to palliate symptoms from brain metastases, to reduce the risk of local relapse after surgical resection, and to improve distant brain control after resection or radiosurgery. While targeting micrometastases throughout the brain can be considered advantageous, the simultaneous exposure of healthy brain tissue might cause adverse events. Attempts to mitigate the risk of neurocognitive decline after WBRT include the selective avoidance of the hippocampi, among others. Besides selective dose reduction, dose escalation to boost volumes, for example, simultaneous integrated boost, aiming at increased tumor control probability is technically feasible. While up-front radiotherapy for newly diagnosed brain metastases often employs radiosurgery or other techniques targeting visible lesions only, sequential (delayed) salvage treatment with WBRT might still become necessary. In addition, the presence of leptomeningeal tumors or very widespread parenchymatous brain metastases might prompt clinicians to prescribe early WBRT.en_US
dc.identifier.citationNieder, Andratschke, Grosu. Brain Metastases: Is There Still a Role for Whole-Brain Radiation Therapy?. Seminars in Radiation Oncology. 2023;33(2):129-138en_US
dc.identifier.cristinIDFRIDAID 2154460
dc.identifier.doi10.1016/j.semradonc.2023.01.005
dc.identifier.issn1053-4296
dc.identifier.issn1532-9461
dc.identifier.urihttps://hdl.handle.net/10037/32691
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalSeminars in Radiation Oncology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titleBrain Metastases: Is There Still a Role for Whole-Brain Radiation Therapy?en_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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