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dc.contributor.authorHegstad, Kristin
dc.contributor.authorPöntinen, Anna Kaarina
dc.contributor.authorBjørnholt, Jørgen
dc.contributor.authorPaulsen, Else Quist
dc.contributor.authorSundsfjord, Arnfinn Ståle
dc.description.abstractObjectives - We describe the first tigecycline resistant enterococcal isolate in Norway and the mechanisms involved.<p> <p>Material and methods - The Norwegian National Advisory Unit on Detection of Antimicrobial Resistance (K-res). received in 2022 an Enterococcus faecium blood culture isolate with decreased susceptibility to tigecycline from a hospitalized patient in the South-Eastern Norway Health region for confirmatory testing. K-res verified a tigecycline-resistant E. faecium (TigR) with broth microdilution MIC of 0.5 mg/L. The patient had received treatment with tigecycline because of an infection with a linezolid- and vancomycin-resistant but tigecycline susceptible E. faecium (TigS) 47 days prior to the detection of the corresponding tigecycline-resistant isolate. Whole-genome comparisons, cgMLST and SNP analyses revealed that the two ST117 strains were closely related.<p> <p>Results - The TigR isolate showed a novel deletion of 2 amino acids (K57Y58) in a polymorphic region of ribosomal protein S10 previously associated with tigecycline resistance and a deletion of the tet(M) leader peptide previously related to increased expression of tet(M) and tigecycline resistance in enterococci.<p> <p>Conclusions - Genomic and epidemiological analyses confirm that the two E. faecium (TigR and TigS) are closely related isolates of the same strain and that the two deletions (in rpsJ and of tet(M) leader peptide) account for the tigecycline resistance in TigR.en_US
dc.identifier.citationHegstad K, Pöntinen AK, Bjørnholt J, Paulsen EL, Sundsfjord A. The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure. Journal of Global Antimicrobial Resistance. 2023;36:112-115en_US
dc.identifier.cristinIDFRIDAID 2222066
dc.relation.journalJournal of Global Antimicrobial Resistance
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleThe first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposureen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)