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dc.contributor.authorSellæg, Kjersti
dc.contributor.authorSchwienbacher, Ruth
dc.contributor.authorKranz, Mathias
dc.contributor.authorEngan Aamodt, Anna
dc.contributor.authorWirsing, Anna Maria
dc.contributor.authorBerge, gerd
dc.contributor.authorHadler-Olsen, Elin Synnøve
dc.contributor.authorNorvoll Magnussen, Synnøve
dc.date.accessioned2024-05-22T10:27:44Z
dc.date.available2024-05-22T10:27:44Z
dc.date.issued2024-05-15
dc.description.abstractOral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity and is associated with high morbidity due to local invasion and lymph node metastasis. Tumor infiltrating lymphocytes (TILs) are associated with good prognosis in oral cancer patients and dictate response to treatment. Ectopic sites for immune activation in tumors, known as tertiary lymphoid structures (TLS), and tumor-associated high-endothelial venules (TA-HEVs), which are specialized lymphocyte recruiting vessels, are associated with a favorable prognosis in OSCC. Why only some tumors support the development of TLS and HEVs is poorly understood. In the current study we explored the infiltration of lymphocyte subsets and the development of TLS and HEVs in oral epithelial lesions using the 4-nitroquinoline 1-oxide (4NQO)- induced mouse model of oral carcinogenesis. We found that the immune response to 4NQO-induced oral epithelial lesions was dominated by T cell subsets. The number of T cells (CD4+, FoxP3+, and CD8+), B cells (B220+) and PNAd+ HEVs increased from the earliest to the latest endpoints. All the immune markers increased with the severity of the dysplasia, while the number of HEVs and B cells further increased in SCCs. HEVs were present already in early-stage lesions, while TLS did not develop at any timepoint. This suggests that the 4NQO model is applicable to study the dynamics of the tumor immune microenvironment at early phases of oral cancer development, including the regulation of TA-HEVs in OTSCC.en_US
dc.identifier.citationSellæg K, Schwienbacher R, Kranz M, Engan Aamodt A, Wirsing AM, Berge g, Hadler-Olsen ES, Norvoll Magnussen S. 4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment. Frontiers in Oncology. 2024en_US
dc.identifier.cristinIDFRIDAID 2269062
dc.identifier.doihttps://doi.org/10.3389/fonc.2024.1343839
dc.identifier.issn2234-943X
dc.identifier.urihttps://hdl.handle.net/10037/33592
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Oncology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.title4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironmenten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)