Institutt for medisinsk biologi: Nye registreringer
Viser treff 261-280 av 1154
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Fibroblast growth factor 2 conjugated with monomethyl auristatin E inhibits tumor growth in a mouse model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-20)Worldwide, cancer is the second leading cause of death. Regardless of the continuous progress in medicine, we still do not have a fully effective anti-cancer therapy. Therefore, the search for new targeted anti-cancer drugs is still an unmet need. Here, we present novel protein–drug conjugates that inhibit tumor growth in a mouse model of human breast cancer. We developed conjugates based on fibroblast ... -
Inhibition of ABCC5-mediated cGMP transport by progesterone, testosterone and their analogues
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-13)The biodynamics and biokinetics of sex hormones are complex. In addition to the classical steroid receptors (nuclear receptors), these hormones act through several non-genomic mechanisms. Modulation of ABC-transporters by progesterone represents a non-genomic mechanism. In the present study, we employed inside out vesicles from human erythrocytes to characterize high affinity cGMP transport by ABCC5 ... -
Strategimøte 2019 - Mikrobiologisk diagnostikk ved virale CNS-infeksjoner
(Research report; Forskningsrapport, 2021-09)I regi av Referansegruppen for ekstern kvalitetssikring i virologi og serologi, ble det den 31.10.2019 holdt strategimøte med temaet «Mikrobiologisk diagnostikk ved virale CNS-infeksjoner» på Gjestehuset, Lovisenberg sykehus i Oslo. Årets strategimøte var en oppdatering av et tidligere strategimøte fra 2002 med samme tittel. Nylig omtalte infeksjoner ble utelatt pga. tidshensyn, deriblant nevroborreliose ... -
NORM/NORM-VET 2020
(Research report; Forskningsrapport, 2021) -
Socioeconomic status and risk of incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-09)Background: Although venous thromboembolism (VTE) is a leading cause of morbidity and mortality, and socioeconomic status (SES) affects human health and health behavior, few studies have examined the association between SES and VTE. Objectives: We aimed to investigate the association between SES, assessed individually and in a composite score by levels of education, income, and employment status, and ... -
Prediction of Eye Colour in Scandinavians Using the EyeColour 11 (EC11) SNP Set
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-27)Description of a perpetrator’s eye colour can be an important investigative lead in a forensic case with no apparent suspects. Herein, we present 11 SNPs (Eye Colour 11-EC11) that are important for eye colour prediction and eye colour prediction models for a two-category reporting system (blue and brown) and a three-category system (blue, intermediate, and brown). The EC11 SNPs were carefully selected ... -
Shotgun-metagenomics based prediction of antibiotic resistance and virulence determinants in Staphylococcus aureus from periprosthetic tissue on blood culture bottles
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-21)Shotgun-metagenomics may give valuable clinical information beyond the detection of potential pathogen(s). Identification of antimicrobial resistance (AMR), virulence genes and typing directly from clinical samples has been limited due to challenges arising from incomplete genome coverage. We assessed the performance of shotgun-metagenomics on positive blood culture bottles (n = 19) with periprosthetic ... -
Erfaringer med økonomiske støtteordninger for tannbehandling hos personer som er behandlet for hode-halskreft
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11)Medlemmer i Munn- og halskreftforeningen mottok et spørreskjema for å kartlegge erfaringer med økonomiske refusjonsordninger for tannbehandling og kostnader til tannbehandling hos personer som er behandlet for hode-halskreft i Norge. I tillegg kartla vi utviklingen i Folketrygdens honorartakster for tannbehandling i perioden 2015-2020, og sammenlignet honorartakstene for 2021 med takstene for ... -
Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-31)Oxidized, damaged and misfolded proteins accumulate during aging and contribute to impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular clearance mechanisms like the 20S proteasome. Aging relates to low 20S proteasome function, whereas long-lived species show high levels. However, contradictory results exist depending on the tissue or cell type and it is ... -
Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant staphylococcus aureus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-29)Methicillin-resistant Staphylococcus aureus (MRSA) has evolved numerous antimicrobial resistance mechanisms and is identified as a serious public health threat by the World Health Organization and U.S. Centers for Disease Control and Prevention. The glycopeptide vancomycin (VAN) remains a cornerstone of therapy for severe MRSA infections despite increasing reports of therapeutic failure in hospitalized ... -
Quantitative analysis methods for studying fenestrations in liver sinusoidal endothelial cells. A comparative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-28)Liver Sinusoidal Endothelial Cells (LSEC) line the hepatic vasculature providing blood filtration via transmembrane nanopores called fenestrations. These structures are 50−300 nm in diameter, which is below the resolution limit of a conventional light microscopy. To date, there is no standardized method of fenestration image analysis. With this study, we provide and compare three different approaches: ... -
The scavenger function of liver sinusoidal endothelial cells in health and disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-11)The aim of this review is to give an outline of the blood clearance function of the liver sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions of hepatic sinusoids in the human liver the LSECs are perfectly located to survey the constituents of the blood. These cells are equipped with high-affinity receptors and an intracellular vesicle transport apparatus, ... -
Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-14)Abstract Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant tamoxifen as initial treatment, we have associated our previously reported thresholds for the two active metabolites, Z‐endoxifen and Z‐4‐hydroxy‐tamoxifen (Z‐4OHtam), ... -
Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant pseudomonas aeruginosa
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-17)Two novel bla<sub>DIM-1</sub>- or bla<SUB>IMP-1</SUB>-containing genomic islands (GIs) were discovered by whole-genome sequence analyses in four extensively drug-resistant (XDR) <i>Pseudomonas aeruginosa</i> isolates from inpatients at a tertiary hospital in Ghana. The strains were of sequence type 234 (ST234) and formed a phylogenetic clade together with ST111, which is recognized as a global ... -
A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)<i>Background</i> - Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT.<br><br> <i>Methods and Materials</i> - We reanalyzed samples originally ... -
Molecular modeling study of the testosterone metabolizing enzyme UDP-glucuronosyltransferase 2B17
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-20)The dominant sex hormone testosterone is mainly metabolized by liver enzymes belonging to the uridine-diphospho (UDP) glucuronosyltransferase (UGT) family. These enzymes are the main phase II enzymes, and they have an important role in the detoxification of endogenous and exogenous compounds in humans. The aim of the present study was to improve the understanding of the binding properties of UGT2B17. ... -
Temporomandibular disorders in an adult population in northern Norway: A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-16)<i>Objectives</i> - The aim of the study was to assess the prevalence of symptoms indicative of temporomandibular disorders (TMD) in an adult population in Troms County in Northern Norway, as well as the associations between TMD and socio-demographic factors, dental status, self-reported general, and oral health as well as oral health related quality of life (OHQoL).<br><br> <i>Methods</i> - Data ... -
Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-05)Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date. The lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1), a specific lymphatic marker, is associated with poor survival in OSCC patients. In this study, we present a potential ... -
The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-20)Oral tongue squamous cell carcinoma (OTSCC) is one of the most common cancers worldwide and is characterized by early metastasis and poor prognosis. Recently, we reported that extracellular interleukin-17F (IL-17F) correlates with better disease-specific survival in OTSCC patients and has promising anticancer effects in vitro. Vasculogenic mimicry (VM) is the formation of an alternative vasculogenic ... -
Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-23)<i>Introduction</i> - Maternal alloimmunization against human platelet antigen (HPA)-1a has been implied to mediate both reduced birth weight and chronic placental inflammation. Fetal growth restriction is associated with different types of chronic inflammation in the placenta, mainly chronic histiocytic intervillositis and chronic villitis. The aim of this prospective study was to do a systematic ...