Institutt for medisinsk biologi: Nye registreringer

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    • Multifaktorielle sykdommer i norsk lakseoppdrett. Sluttrapport 

      Johansen, Lill-Heidi; Bang-Jensen, Berit; Jansen, Mona Dverdal; Taksdal, Torunn; Krasnov, Aleksei (Research report; Forskningsrapport, 2015-07-02)
      Prosjektet «Multifaktorielle sykdommer i norsk lakseoppdrett» er utført i et samarbeid mellom Nofima, Veterinærinstituttet, AquaGen AS og Patogen AS. Hovedmålet for prosjektet var å øke kunnskapen om utviklingen av multifaktorielle sykdommer ved å vurdere effekten av ulike variabler og deres interaksjon. Effekten av ulike variabler (genetisk resistens mot IPN, IPNV bærer status, IPNV reaktivering ...

    • A survey of dioxin-like contaminants in fish from recreational fishing. 

      Heimstad, Eldbjørg Sofie; Grønstøl, Gaute; Hetland, Karl Torstein; Alarcon, Javier Martinez; Rylander, Charlotta; Mariussen, Espen (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-19)
      The dioxin and dioxin-like compounds are regarded as one of the most toxic group of environmental contaminants. Food for the commercial market is regularly monitored for their dioxin levels and the concentration allowed in food is strictly regulated. Less is known about locally caught fish from recreational fishing, which is often brought home for consumption. This can be fish caught from nearby ...

    • Temperature during early development has long-term effects on microRNA expression in Atlantic cod 

      Bizuayehu, Teshome Tilahun; Johansen, Steinar D; Puvanendran, Velmurugu; Toften, Hilde; Babiak, Igor (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-17)
      Background: Environmental temperature has serious implications in life cycle of aquatic ectotherms. Understanding the molecular mechanisms of temperature acclimation and adaptation of marine organisms is of the uttermost importance for ecology, fisheries, and aquaculture, as it allows modeling the effects of global warming on population dynamics. Regulatory molecules are major modulators of acclimation ...

    • Detection of Anaplasma phagocytophilum in Ixodes ricinus ticks from Norway using a realtime PCR assay targeting the Anaplasma citrate synthase gene gltA 

      Henningsson, Anna J.; Hvidsten, Dag; Kristiansen, Bjørn Erik; Matussek, Andreas; Stuen, Snorre; Jenkins, Andrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-01)
      Background: A TaqMan real-time PCR assay targeting the Anaplasma citrate synthase gene, gltA, was developed and used for detection of Anaplasma phagocytophilum in 765 Ixodes ricinus ticks collected from dogs and cats in northern Norway (n = 669) and Telemark county in southern Norway (n = 96). Results: Among the ticks from northern Norway the prevalence of A. phagocytophilum was 3.0 %, while the ...

    • Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis 

      Mikalsen, Theresa; Pedersen, Torunn Annie; Willems, Rob J; Coque, Teresa M.; Werner, Guido; Sadowy, Eva; van Schaik, Willem; Jensen, Lars Bogø; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-10)
      Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance genes encoded by mobile genetic elements (MGE). Here, we investigate this mobilome in successful hospital associated genetic lineages, E. faecium sequence type (ST)17 (n=10) and ...

    • Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers 

      Hadler-Olsen, Elin Synnøve; Solli, Ann Iren; Hafstad, Anne Dragøy; Winberg, Jan-Olof; Uhlin-Hansen, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-29)
      Matrix metalloproteinase 2 (MMP-2) is a proteolytic enzyme implicated in motility, differentiation, and regeneration of skeletal muscle fibers through processing of extracellular substrates. Although MMP-2 has been found to be localized intracellularly in cardiomyocytes where the enzyme is thought to contribute to post-ischemic loss of contractility, little is known about intracellular MMP-2 activity ...

    • Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40 

      Zischka, Melanie; Künne, Carsten T.; Blom, Jochen; Wobser, Dominique; Sakιnç, Türkân; Schmidt-Hohagen, Kerstin; Dabrowski, P. Wojtek; Nitsche, Andreas; Hübner, Johannes; Hain, Torsten; Chakraborty, Trinad; Linke, Burkhard; Goesmann, Alexander; Voget, Sonja; Daniel, Rolf; Schomburg, Dietmar; Hauck, Rüdiger; Hafez, Hafez M.; Tielen, Petra; Jahn, Dieter; Solheim, Margrete; Sadowy, Ewa; Larsen, Jesper; Jensen, Lars Bogø; Ruiz-Garbajosa, Patricia; Pérez, Dianelys Quiñones; Mikalsen, Theresa; Bender, Jennifer; Steglich, Matthias; Nübel, Ulrich; Witte, Wolfgang; Werner, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-12)
      Background: Enterococcus faecalis is a multifaceted microorganism known to act as a beneficial intestinal commensal bacterium. It is also a dreaded nosocomial pathogen causing life-threatening infections in hospitalised patients. Isolates of a distinct MLST type ST40 represent the most frequent strain type of this species, distributed worldwide and originating from various sources (animal, human, ...

    • Complete mitochondrial genome sequences of the Arctic Ocean codfishes Arctogadus glacialis and Boreogadus saida reveal oriL and tRNA gene duplications 

      Breines, Ragna; Ursvik, Anita; Nymark, Marianne; Johansen, Steinar; Coucheron, Dag-Hugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-05-27)
      We have determined the complete mitochondrial genome sequences of the codWshes Arctogadus glacialis and Boreogadus saida (Order Gadiformes, Family Gadidae). The 16,644 bp and 16,745 bp mtDNAs, respectively, contain the same set of 37 structural genes found in all vertebrates analyzed so far. The gene organization is conserved compared to other Gadidae species, but with one notable exception. ...

    • Oncolytic Activity and Mechanisms of Action by a small β2,2-amino acid derivative LTX-401 

      Mauseth, Brynjar (Master thesis; Mastergradsoppgave, 2015-05-11)
      Antimicrobial peptides are part of the innate immune defence of many organisms and represent a novel class of therapeutics due to their broad-spectrum activities, including cytotoxic activity against cancer cells. It has recently been reported that small antimicrobial β2,2-amino acid derivatives (Mw<500), such as LTX-401, possess potent anticancer activity against Ramos human Burkitt’s lymphoma ...

    • A study of possible genetic causes of inherited breast and ovarian cancer in a Norwegian cancer population 

      Jarhelle, Elisabeth (Master thesis; Mastergradsoppgave, 2013-05-15)
      Homologous recombination repair (HRR) is an important repair mechanism, and mutations disrupting the function of this machinery might contribute to cancer formation. Several proteins interact in this mechanism, and the two best known are BRCA1 and BRCA2. Mutations in their corresponding genes BRCA1 and BRCA2 are found in 40% of hereditary breast and ovarian cancer cases. However, there are still ...

    • Identification, isolation and characterisation of scavenging endothelial cells in placenta 

      Mjølsnes, Nina (Master thesis; Mastergradsoppgave, 2014-05-15)
      Haemopoiesis occurs in the BM, where haemopoietic stem cells (HSC) reside in a three-dimensional “niche” and give rise to the millions of circulating blood cells required everyday of life. The precise regulation of this immense task occurs by interaction of HSC with other BM cells and extracellular matrix molecules. In addition, the BM vasculature has also now been identified as a key HSC regulator. ...

    • Role of the mannose receptor in tumor associated macrophages. Studies in a mouse melanoma model 

      Rønningen, Iselin (Master thesis; Mastergradsoppgave, 2014-04-15)
      Tumor-associated macrophages (TAMs) play an important role in cancer-related inflammation. TAMs develop M2 polarization which may support tumor growth. Mannose receptor (MR) expression is a hallmark for this cell-subpopulation, and the MR has recently been suggested to be involved in TAM polarization. The aim of the study was to investigate the role of MR in TAM polarization and tumor development ...

    • miR-126 as a prognostic marker in non-GIST soft tissue sarcoma 

      Persson, Magnus Lennart (Master thesis; Mastergradsoppgave, 2014-04-10)
      The aim of the study was to study the prognostic impact of miRNAs in non-GIST soft tissue sarcoma. The method used was microarray-based miRNA expression profiling of all verified human miRNAs on a selected number of samples. Selection criteria was time of survival (long and short). Then, the significance of miR-126 expression for disiease-specific survival in the total patient cohort of non-GIST ...

    • Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus heamolyticus in European hopsitals 

      Cavanagh, Jorunn Pauline; Hjerde, Erik; Holden, Matthew T.G.; Kahlke, Tim; Klingenberg, Claus; Flægstad, Trond; Parkhill, J; Bentley, Stephen D; Sollid, Johanna U Ericson (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Levonorgestrel-impregnated intrauterine device as treatment for endometrial hyperplasia: A national multicentre randomised trial 

      Ørbo, Anne; Vereide, Anne Beate; Arnes, Marit; Pettersen, Inger; Straume, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort 

      Engeset, Dagrun; Braaten, Tonje; Teucher, Birgit; Kuhn, Tilman; Bueno-de-Mesquita, HB; Leenders, Max; Agudo, Antonio; Bergmann, Manuela M; Valanou, Elisavet; Naska, Androniki; Trichopoulou, Antonia; Key, Timothy J; Crowe, Francesca L; Overvad, Kim; Sonestedt, Emily; Mattiello, Amalia; Peeters, Petra H; Wennberg, Maria; Jansson, Jan Håkan; Boutron-Ruault, Marie-Christine; Dossus, Laure; Dartois, Laureen; Li, Kuanrong; Barricarte, Aurelio; Ward, Heather; Riboli, Elio; Agnoli, Claudia; Huerta, Jose Maria; Sanchez, Maria-Jose; Tumino, Rosario; Altzibar, Jone M; Vineis, Paolo; Masala, Giovanna; Ferrari, Pietro; Muller, David C; Johansson, Mattias; Luisa Redondo, M; Tjønneland, A; Olsen, Anja; Olsen, Karina Standahl; Brustad, Magritt; Skeie, Guri; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Estimating QUALY gains in applied studies: A review of cost-utility analyses published in 2010 

      Wisløff, Torbjørn; Hagen, Gunhild; Hamidi, Vida; Movik, Espen; Klemp, Marianne; Olsen, Jan Abel (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315 

      Camilio, Ketil André; Berge, Gerd; Ravuri, Chandra Sekhar; Rekdal, Øystein; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Low FEV1, smoking history, and obesity are factors associated with oxygen saturation decrease in an adult population cohort 

      Vold, Monica Linea; Aasebø, Ulf; Melbye, Hasse (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Midwives’ Adherence to Preoperative Care Guidelines Prior to Emergency Caesarean Section at Bwaila Maternity Hospital in Malawi 

      Mwale, Ruth; Maluwa, Alfred; Malata, Address; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)