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dc.contributor.authorSoløy-Nilsen, Hedda
dc.contributor.authorNygaard-Odeh, Kristin
dc.contributor.authorKristiansen, Magnhild Gangsøy
dc.contributor.authorKvig, Erling Inge
dc.contributor.authorBrekke, Ole Lars
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorBerk, Michael
dc.contributor.authorReitan, Solveig Klæbo
dc.contributor.authorØiesvold, Terje
dc.date.accessioned2024-10-01T12:08:11Z
dc.date.available2024-10-01T12:08:11Z
dc.date.issued2023-07-17
dc.description.abstractObjective: Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform pathobiology and treatment opportunities. The aim of this study is to explore if there are associations between cytokines and psychiatric symptom clusters. Comparison between patients regularly using and those not using psychotropic medication is also conducted.<p> <p>Methods: This was a cross sectional naturalistic study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Norway. Serum levels of 28 different cytokines were assessed. Psychiatric symptoms the last week were assessed by a self-rating scale (Symptom check list, SCL-90-R) and grouped in defined clusters. Multiple linear regression model was used for statistical analyses of associations between levels of cytokines and symptoms, adjusting for possible confounding factors.<p> <p> Results: We found a positive association (p = 0.009) between the chemokine interferon-gamma inducible protein 10 (CXCL 10; IP-10) and the anger hostility cluster. No associations were found between the other symptom clusters and cytokines. IP-10 and the anger hostility cluster were positively associated (p = 0.002) in the subgroup of patients using psychotropic medication, not in the subgroup not using psychotropic medication.<p> <p>Conclusion: Our analyses revealed a significant positive association between the symptom cluster anger hostility in SCL-90-R and the chemokine IP-10 in the subgroup of patients using psychotropic medications.en_US
dc.identifier.citationSoløy-Nilsen, Nygaard-Odeh, Kristiansen, Kvig, Brekke, Mollnes, Berk, Reitan, Øiesvold. Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10. Clinical Psychopharmacology and Neuroscience. 2024;22(2):285-294en_US
dc.identifier.cristinIDFRIDAID 2265677
dc.identifier.doi10.9758/cpn.23.1091
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.urihttps://hdl.handle.net/10037/34954
dc.language.isoengen_US
dc.publisherThe Korean College of Neuropsychopharmacologyen_US
dc.relation.journalClinical Psychopharmacology and Neuroscience
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleTransdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)