Tigecycline attenuates polymorphonuclear leukocyte (PMN) receptors but not functions
Permanent lenke
https://hdl.handle.net/10037/3903DOI
doi: 10.2478/v10007-011-0024-4Dato
2011Type
Journal articleTidsskriftartikkel
Peer reviewed
Sammendrag
Tigecycline achieves high intracellular concentrations in polymorphonuclear leukocytes (PMNs). To evaluate the effects of tigecycline on human PMNs, PMNs were incubated with tigecycline dilutions (0.1 to 100 mg L–1). Phagocytosis-
associated PMN Fcg- and complement receptors
as well as phagocytosis and oxidative burst induced by Staphylococcus aureus were measured by flow cytometry. Incubation with tigecycline caused small but significant decreases in the density of complement receptors CD11b and CD35 (all concentrations) and Fcg receptors CD16 and
CD32 (high concentrations), but not in the percentages of receptor-bearing cells, except for small reductions in the proportions of CD16 positive cells at high concentrations. Tigecycline had no effect on phagocytosis or oxidative burst induced by S. aureus. Tigecycline was thus associated with decreased density of PMN complement and (at high concentrations) Fcg receptors. Although statistically significant, the differences were small and did not influence
the PMN function as measured by phagocytosis and
oxidative burst.
Forlag
VersitaSitering
Acta Pharmaceutica 61(2011) s. 297-302Metadata
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