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dc.contributor.authorValkov, Andrey Yurjevich
dc.contributor.authorSørbye, Sveinung Wergeland
dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorDønnem, Tom
dc.contributor.authorSmeland, Eivind
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorBusund, Lill-Tove
dc.date.accessioned2012-03-12T12:28:57Z
dc.date.available2012-03-12T12:28:57Z
dc.date.issued2011
dc.description.abstractTransforming growth factor-β (TGF-β), fascin, nuclear factor-kappa B (NF-κB) p105, protein-kinase C-zeta (PKC-ζ), partioning-defective protein-6 (Par-6), E-cadherin and vimentin are tumor promoting molecules through mechanisms involved in cell dedifferentiation. In soft tissue sarcomas, their expression profile is poorly defined and their significance is uncertain. We aimed to investigate the prognostic impact of TGF-β1, NF-κB p105, PKC-ζ, Par-6α, E-cadherin and vimentin in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STSs). Tumor samples and clinical data from 249 patients with non-GIST STS were obtained, and tissue microarrays (TMAs) were constructed for each specimen. Immunohistochemistry (IHC) was used to evaluate marker expression in tumor cells. In univariate analysis, the expression levels of TGF-β1 (P = 0.016), fascin (P = 0.006), NF-κB p105 (P = 0.022) and PKC-ζ, (P = 0.042) were significant indicators for disease specific survival (DSS). In the multivariate analysis, high TGF-β1 expression was an independent negative prognostic factor for DSS (HR = 1.6, 95% CI = 1.1–2.4, P = 0.019) in addition to tumor depth, malignancy grade, metastasis at diagnosis, surgery and positive resection margins. Expression of TGF-β1 was significantly associated with aggressive behavior and shorter DSS in non-GIST STSs.en
dc.descriptionThis paper is part of Andrey Yurjevich Valkovs doctoral thesis. Available in Munin at <a href=http://hdl.handle.net/10037/4578>http://hdl.handle.net/10037/4578</a>
dc.identifier.citationPLoS ONE (2011) 6(3): e17507en
dc.identifier.issn1932-6203
dc.identifier.otherFRIDAID 828527
dc.identifier.otherdoi: 10.1371/journal.pone.0017507
dc.identifier.urihttp://hdl.handle.net/10037/3931
dc.identifier.urnURN:NBN:no-uit_munin_3653
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.titleThe Prognostic Impact of TGF-beta 1, Fascin, NF-kappa B and PKC-zeta Expression in Soft Tissue Sarcomasen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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