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dc.contributor.authorAlemu, Endalkachew
dc.contributor.authorSjøttem, Eva
dc.contributor.authorOutzen, heidi
dc.contributor.authorLarsen, Kenneth Bowitz
dc.contributor.authorHolm, turid
dc.contributor.authorBjørkøy, Geir
dc.contributor.authorJohansen, Terje
dc.date.accessioned2012-03-14T08:39:19Z
dc.date.available2012-03-14T08:39:19Z
dc.date.issued2011
dc.description.abstractThe protein kinase C (PKC) family of serine/threonine kinases consists of ten different isoforms grouped into three subfamilies, denoted classical, novel and atypical PKCs (aPKCs). The aPKCs, PKC?/? and PKC? serve important roles during development and in processes subverted in cancer such as cell and tissue polarity, cell proliferation, differentiation and apoptosis. In an effort to identify novel interaction partners for aPKCs, we performed a yeast two-hybrid screen with the regulatory domain of PKC?/? as bait and identified the Krüppel-like factors family protein TIEG1 as a putative interaction partner for PKC?/?. We confirmed the interaction of both aPKCs with TIEG1 in vitro and in cells, and found that both aPKCs phosphorylate the DNA-binding domain of TIEG1 on two critical residues. Interestingly, the aPKC-mediated phosphorylation of TIEG1 affected its DNA-binding activity, subnuclear localization and transactivation potential.Transforming growth factor-ß-inducible early response gene 1 is a novel substrate for atypical protein kinase Csen
dc.identifier.citationCellular and Molecular Life Sciences 68(2011) nr. 11 s. 1953-1968en
dc.identifier.cristinIDFRIDAID 698907
dc.identifier.doidoi: 10.1007/s00018-010-0541-1
dc.identifier.issn1420-682X
dc.identifier.urihttps://hdl.handle.net/10037/3953
dc.identifier.urnURN:NBN:no-uit_munin_3675
dc.language.isoengen
dc.publisherSpringeren
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical genetics: 714en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714en
dc.title.alternativeTransforming growth factor-ß-inducible early response gene 1 is a novel substrate for atypical protein kinase Csen
dc.titleTransforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Csen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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