Now showing items 3516-3535 of 5482

    • Novel inotropic strategies for treating acute heart failure: A large animal study on cardiac function and energetics 

      Bakkehaug, Jens Petter (Doctoral thesis; Doktorgradsavhandling, 2017-02-16)
      Acute heart failure (AHF) is a disease with a mortality ranging from 5 to 40% depending on severity, despite modern revascularization techniques after acute myocardial thromboembolism. In this thesis we have investigated two new concepts of treating AHF. In paper 1 we investigated the combination of dobutamine and ivabradine (D+I) in a porcine model of stunning AHF. Ivabradine attenuated the ...
    • Novel liposome formulation from algae membranes as carriers for bioactive compounds 

      Troyan, Anna Nikolaevna (Master thesis; Mastergradsoppgave, 2014-05-20)
      Liposomes are lipid-based systems which have the ability to incorporate various chemical substances and thus can be used for drug delivery purposes. Liposomes are composed of phospholipids, flexible in composition, and have shown great potential to improve delivery and targeting of bioactive substances which otherwise have poor bioavailability in the body. Conventional liposomes composed of various ...
    • A novel non-canonical Wnt signature for prostate cancer aggressiveness 

      Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-24)
      Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A newly discovered NCWP, Wnt5/Fzd2, has been shown to induce epithelial-to-mesenchymal transition (EMT) in cancers, but has not been investigated in prostate cancer. The aim of this ...
    • The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma 

      Mauseth, Brynjar; Camilio, Ketil Andre; Shi, Jihua; Hammarström, Clara Louise; Rekdal, Øystein; Sveinbjørnsson, Baldur; Line, Pål Dag (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-21)
      LTX-401 is a novel oncolytic compound designed for the local treatment of solid tumors. In the present study, we have examined the applicability and efficacy of LTX-401 in a rat model JM1 hepatocellular carcinoma, with particular interest in its ability to induce antitumor immunity. LTX-401 induces necrotic cell death followed by the release of immunogenic cell death mediators such as high-mobility ...
    • Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population 

      Scuda, Nelly; Madinda, Nadege; Akoua-Koffi, Chantal; Adjogoua, Edgard V; Wevers, Diana; Hofmann, Jörg; Cameron, Kenneth M.; Leendertz, Siv Aina Jensen; Couacy-Hymann, Emmanuel; Robbins, Martha M.; Boesch, Christophe; Jarvis, Michael; Moens, Ugo; Calvignac-Spencer, Sébastien; Leendertz, Fabian H; Ehlers, Bernhard; Ehlers, B (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Polyomaviruses are a family of small non-enveloped DNA viruses that encode oncogenes and have been associated, to greater or lesser extent, with human disease and cancer. Currently, twelve polyomaviruses are known to circulate within the human population. To further examine the diversity of human polyomaviruses, we have utilized a combinatorial approach comprised of initial degenerate primer-based ...
    • A novel risk classification system for preconception health and sero-epidemiological map of Toxoplasma, Rubella and Cytomegalovirus infections among couples planning a pregnancy in rural China: A nationwide study 

      Zhou, Qiongjie (Doctoral thesis; Doktorgradsavhandling, 2019-08-30)
      <i>Objectives</i> - The aim of this thesis was to evaluate the feasibility, effectiveness and impact of preconception health screening strategy and a novel risk classification system of China`s “National Preconception Health Care Project (NPHCP)” in identifying risk factors and stratifying couples’ preconception care (PCC), and to establish a sero-epidemiological map of TORC infections in the ...
    • Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors 

      Czarna, Anna Lucja; Jinhua, Wang; Zelencova, Diana; Liu, Yao; Deng, Xianming; Choi, Hwan Geun; Zhang, Tinghu; Zhou, Wenjun; Chang, Jae Won; Kildalsen, Hanne; Seternes, Ole Morten; Gray, Nathanael S.; Engh, Richard Alan; Rothweiler, Ulli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-10)
      DYRK1A is one of five members of the dual-specificity tyrosine (Y) phosphorylation-regulated kinase (DYRK) family. The DYRK1A gene is located in the Down syndrome critical region and regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells during early development. This has focused research on its role in neuronal degenerative diseases, including ...
    • A novel scale-space approach for multinormality testing and the k-sample problem in the high dimension low sample size scenario 

      Hindberg, Kristian; Hannig, Jan; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
      Two classical multivariate statistical problems, testing of multivariate normality and the <i>k</i>-sample problem, are explored by a novel analysis on several resolutions simultaneously. The presented methods do not invert any estimated covariance matrix. Thereby, the methods work in the High Dimension Low Sample Size situation, i.e. when <i>n</i> ≤ <i>p</i>. The output, a significance map, is ...
    • Novel targets for delaying aging: The importance of the liver and advances in drug delivery 

      Hunt, Nicholas J; McCourt, Peter Anthony; Le Couteur, David George; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2018-09-21)
      Age-related changes in liver function have a significant impact on systemic aging and susceptibility to age-related diseases. Nutrient sensing pathways have emerged as important targets for the development of drugs that delay aging and the onset age-related diseases. This supports a central role for the hepatic regulation of metabolism in the association between nutrition and aging. Recently, a role ...
    • De novo sequencing of disulphide rich peptides using tandem mass spectrometry 

      Chala, Regasa (Master thesis; Mastergradsoppgave, 2015-05-13)
      Peptide based drugs have been shown to have better target selectivity and thereby better safety profile than many small molecule drug candidates. This led many researchers and drug companies to show an increasing interest toward bioactive peptides. Developing an effective analytical method for peptide /protein structural identification is a cornerstone to meet this expanding area of research in this ...
    • NUBU 4-16, nyttig for fysioterapipraksis? : en kvalitativ intervjuundersøkelse basert på fysioterapeuters erfaringer med undersøkelsen 

      Ellefsen, Mari (Master thesis; Mastergradsoppgave, 2012-05-15)
      Bakgrunn: Barnefysioterapeuter har i økende grad tatt inn og begynt å bruke standardiserte undersøkelsesmetoder. Det finnes flere undersøkelsesmetodikker til å kartlegge og få innsikt i barns motoriske kompetanse, og det kan være utfordrende å vite hvilke man skal bruke. I 2008 ble en nevromotorisk undersøkelse for barn og ungdom, NUBU 4-16, lansert. Hensikt: Å få økt innsikt og kunnskap om hvordan ...
    • Nuclear group I introns in self-splicing and beyond 

      Hedberg, Annica; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Group I introns are a distinct class of RNA self-splicing introns with an ancient origin. All known group I introns present in eukaryote nuclei interrupt functional ribosomal RNA genes located in ribosomal DNA loci. The discovery of the Tetrahymena intron more than 30 years ago has been essential to our understanding of group I intron catalysis, higher-order RNA structure, and RNA folding, but ...
    • Nuclear Legumain Activity in Colorectal Cancer 

      Haugen, Mads Haugland; Johansen, Harald Thidemann; Pettersen, Solveig; Solberg, Rigmor; Brix, Klaudia; Flatmark, Kjersti; Mælandsmo, Gunhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The cysteine protease legumain is involved in several biological and pathological processes, and the protease has been found over-expressed and associated with an invasive and metastatic phenotype in a number of solid tumors. Consequently, legumain has been proposed as a prognostic marker for certain cancers, and a potential therapeutic target. Nevertheless, details on how legumain advances ...
    • Nucleophilic Substitution Reactions for Positron Emission Tomography; Factors Influencing the Reactivity of [18F]Fluoride 

      Svadberg, Anders (Doctoral thesis; Doktorgradsavhandling, 2012-03-02)
      Clinical use of positron emission tomography (PET) is expanding from use of [18F]FDG to a wider spectrum of PET-tracers and proprietary PET radiopharmaceuticals. The development of new PET-tracers is however far from trivial and the radiochemistry is a major limiting factor. Nucleophilic substitution reactions with [18F]fluoride generally suffer from inconsistent labeling yields. There is a need to ...
    • Nucleus ratio associated with malignancy in gastrointestinal stromal tumors. A morphometric study of 39 patients 

      Andersen, Øyvind S. (Master thesis; Mastergradsoppgave, 2006-09-01)
    • Nursing documentation as a communication tool : (a case study from Ghana) 

      Johnson, Beatrice Bella (Master thesis; Mastergradsoppgave, 2011-05-30)
      Quality patient’s information has been proven to enhance the quality of care the patients receive as well as the guarantee of their safety. This is because information would be available to inform others and subsequently aid appropriate decision making concerning patients care. On the other hand, nurses being the professionals who spend twenty-four hours with the patients have a lot of information ...
    • Nursing homes as learning environments : a study of experiences and perceptions of nursing students and supervising nurses 

      Skaalvik, Mari Wolff (Doctoral thesis; Doktorgradsavhandling, 2010-06-03)
      Avhandlingen bygger på 12 sykepleiestudenters erfaringer og oppfatninger om sykehjem som læringsmiljø for praksisstudier i eldreomsorg, og hvordan et utvalg på 407 norske sykepleierstudenter evaluerer læringsmiljøet i sykehjem og sykehus. Videre har jeg intervjuet 11 sykepleiere om deres syn på læringsmiljøet i sykehjem. <br>Levealderen i Norge ventes å øke, og man må regne med at fremtidens ...
    • The Nursing Legacy of The Korea Sisters 

      Lockertsen, Jan-Thore; Fause, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-27)
      Aim<br> During the Korean War (1950–1953), the Norwegian government sent a Mobile Army Surgical Hospital (MASH) to support the efforts of the United Nations (UN) Army. During the war, 111 Norwegian nurses served in seven contingents, each 6 month, at the Norwegian Field Hospital in Korea. The nurses were nicknamed “The Korea Sisters”. The aim of this study is to explore the impact and influence of ...
    • Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study 

      Freisling, Heinz; Noh, Hwayoung; Slimani, Nadia; Chajès, Véronique; May, Anne M.; Peeters, Petra H; Weiderpass, Elisabete; Cross, Amanda J.; Skeie, Guri; Jenab, Mazda; Mancini, Francesca Romana; Boutron-Ruault, Marie-Christine; Fagherazzi, Guy; Katzke, Verena A.; Kühn, Tilman; Steffen, Annika; Boeing, Heiner; Tjønneland, Anne; Kyrø, Cecilie; Hansen, Camilla P.; Overvad, Kim; Duell, Eric J.; Redondo-Sánchez, Daniel; Amiano, Pilar; Navarro, Carmen; Barricarte, Aurelio; Perez-Cornago, Aurora; Tsilidis, Konstantinos K.; Aune, Dagfinn; Ward, Heather; Trichopoulou, Antonia; Naska, Androniki; Orfanos, Philippos; Masala, Giovanna; Agnoli, Claudia; Berrino, Franco; Tumino, Rosario; Sacerdote, Carlotta; Mattiello, Amalia; Bueno-De-Mesquita, Hendrik Bastiaan; Ericson, Ulrika; Sonestedt, Emily; Winkvist, Anna; Braaten, Tonje; Romieu, Isabelle; Sabaté, Joan (Journal article; Tidsskriftartikkel; Manuskript; Peer reviewed; Preprint, 2017-07-21)
      <p><i>Purpose</i>: There is inconsistent evidence regarding the relationship between higher intake of nuts, being an energy-dense food, and weight gain. We investigated the relationship between nut intake and changes in weight over 5 years.</p> <p><i>Methods</i>: This study includes 373,293 men and women, 25–70 years old, recruited between 1992 and 2000 from 10 European countries in the European ...
    • Nutrient patterns and their food sources in an international study setting: Report from the EPIC study 

      Moskal, Aurelie; Pisa, Pedro T; Ferrari, Pietro; Byrnes, Graham; Freisling, Heinz; Boutron-Ruault, Marie-Christine; Cadeau, Claire; Nailler, Laura; Wendt, Andrea; Kühn, Tilman; Boeing, Heiner; Buijsse, Brian; Tjønneland, Anne; Halkjær, Jytte; Dahm, Christina C; Chiuve, Stephanie E; Quirós, Jose R; Buckland, Genevieve; Molina-Montes, Esther; Amiano, Pilar; Huerta Castaño, José M; Gurrea, Aurelio Barricarte; Khaw, Kay-Tee; Lentjes, Marleen A; Key, Timothy J; Romaguera, Dora; Vergnaud, Anne-Claire; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Sacerdote, Carlotta; De Magistris, Maria Santucci; Bueno-de-Mesquita, H Bas; Ocké, Marga C; Beulens, Joline W J; Ericson, Ulrika; Drake, Isabel; Nilsson, Lena M; Winkvist, Anna; Weiderpass, Elisabete; Hjartåker, Anette; Riboli, Elio; Slimani, Nadia (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)