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    • Large-Scale EHR Suites and Path-Dependence 

      Ellingsen, Gunnar; Hertzum, Morten; Christensen, Bente; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-29)
      Large-scale electronic health record (EHR) suites are expected to cover a broad range of use scenarios for healthcare workers in hospitals, nursing homes, home-care services, and general practitioner (GP) clinics. However, preparation for the implementation of EHR suites requires years of detailed planning and consumes considerable financial and human resources. A key problem, then, is that there ...

    • A large-scale exome array analysis of venous thromboembolism 

      Lindström, Sara; Brody, Jennifer A.; Turman, Constance; Germain, Marine; Bartz, Traci M.; Smith, Erin N.; Chen, Ming-Huei; Puurunen, Marja; Chasman, Daniel; Hassler, Jeffrey; Pankratz, Nathan; Basu, Saonli; Guan, Weihua; György, Beata; Ibrahim, Manal; Empana, Jean-Philippe; Olaso, Robert; Jackson, Rebecca; Brækkan, Sigrid Kufaas; McKnight, Barbara; Deleuze, Jean-François; O'Donnell, Christopher J.; Jouven, Xavier; Frazer, Kelly A.; Psaty, Bruce M.; Wiggins, Kerri L.; Taylor, Kent; Reiner, Alexander P.; Heckbert, Susan R.; Kooperberg, Charles; Ridker, Paul; Hansen, John-Bjarne; Tang, Weihong; Johnson, Andrew D.; Morange, Pierre-Emmanuel; Trégouët, David A.; Kraft, Peter; Smith, Nicholas L.; Kabrhel, Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-19)
      Although recent Genome‐Wide Association Studies have identified novel associations for common variants, there has been no comprehensive exome‐wide search for low‐frequency variants that affect the risk of venous thromboembolism (VTE). We conducted a meta‐analysis of 11 studies comprising 8,332 cases and 16,087 controls of European ancestry and 382 cases and 1,476 controls of African American ancestry ...

    • Large-scale secretome analyses unveil the superior immunosuppresive phenotype of umbilical cord stromal cells as compared to other adult mesenchymal stromal cells 

      Islam, Md Ashraful; Urbarova, Ilona; Bruun, Jack-Ansgar; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-20)
      Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about the divergence of these signalling molecules in different MSC populations. The present study investigated ...

    • Laser In Situ Keratomileusis (LASIK) Combined with Prophylactic Corneal Cross-Linking for Correction of Myopia: Regional Analysis of Corneal Morphology 

      Zhang, Jia; Chen, Tong; Wang, Junjie; Bao, Fangjun; Chen, Wen; Stojanovic, Aleksandar; Wang, Qinmei; Chen, Shihao (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-09)
      Introduction: This study evaluated the outcomes of laser in situ keratomileusis (LASIK) combined with prophylactic corneal collagen cross-linking (CXL) in correcting myopia in cases with increased estimated risk of postoperative corneal ectasia, detected by regional analysis of corneal morphology.<p> <p>Methods: The retrospective study included 180 eyes of 99 patients. Group 1 (94 eyes of ...

    • Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population 

      Maniaol, Angelina; Elsais, Ahmed; Lorentzen, Åslaug Rudjord; Owe, Jone Furulund; Viken, Marte K; Sæther, Hanne Skarpodde; Flåm, Siri Tennebø; Bråthen, Geir; Kampman, Margitta Theodora; Midgard, Rune; Christensen, Marte; Rognerud, Anna Kaja; Kerty, Emilia; Gilhus, Nils Erik; Tallaksen, Chantal; Lie, Benedicte Alexandra; Harbo, Hanne Flinstad (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Acquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune disease caused by impaired neuromuscular transmission, leading to abnormal muscle fatigability. The aetiology is complex, including genetic risk factors of the human leukocyte antigen (HLA) complex and unknown environmental factors. Although associations between the HLA complex and MG are well established, not all involved ...

    • Late Window Imaging Selection for Endovascular Therapy of Large Vessel Occlusion Stroke: An International Survey 

      Nguyen, Thanh; Klein, Piers; Berberich, Anne; Nagel, Simon; Abdalkader, Mohamad; Herning, Ana; Kristoffersen, Espen Saxhaug; Sandset, Else Charlotte (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-31)
      Background - Current stroke guidelines recommend advanced imaging (computed tomography [CT] perfusion or magnetic resonance imaging) prior to endovascular therapy (EVT) in patients with late presentation of large vessel occlusion. Adherence to guidelines may be constrained by resources or timely access to imaging. We sought to understand the factors which influence late window imaging selection for ...

    • Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study 

      Huncikova, Zuzana; Vatne, Anlaug; Stensvold, Hans Jørgen; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Salvesen, Bodil; Øymar, Knut Asbjørn Alexander; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-02)
      Objective To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS).<p> <p>Design Cohort study using a nationwide, population-based registry. <p>Setting 21 neonatal units in Norway. <p>Participants All very preterm infants born 1 January 2009–31 December 2018 and admitted to a neonatal ...

    • Latent semantic variables are associated with formal thought disorder and adaptive behavior in older inpatients with schizophrenia 

      Holshausen, Katherine; Harvey, Philip D.; Elvevåg, Brita; Foltz, Peter; Bowie, Christopher R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Introduction: Formal thought disorder is a hallmark feature of schizophrenia in which disorganized thoughts manifest as disordered speech. A dysfunctional semantic system and a disruption in executive functioning have been proposed as possible mechanisms for formal thought disorder and verbal fluency impairment. Traditional rating scales and neuropsychological test scores might not be sensitive ...

    • Laterale ankelligamentskader 

      Brun, Ole-Christian L.; Stødle, Are Haukåen; Molund, Marius; Hvaal, Kjetil (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-13)
      Laterale ankelligamentskader oppstår i forbindelse med inversjonstraumer og er en av de vanligste skadene både i den generelle befolkningen og blant aktive idrettsutøvere. En lateral ankelligamentskade svekker stabiliserende strukturer i ankelen og kan disponere for vedvarende instabilitet i ankelleddet. Akutte laterale ankelligamentskader uten mistanke om brudd kan behandles og følges opp konservativt ...

    • Lav fødselsvekt som risikofaktor for redusert nyrefunksjon i en frisk middelaldrende populasjon. 

      Beck, Simone; Larsen, Malin (Master thesis; Mastergradsoppgave, 2016-05-19)
      Lav fødselsvekt er en foreslått risikofaktor for utvikling av kronisk nyresykdom. I denne studien har vi sett nærmere på om det finnes en sammenheng mellom fødselsvekt og GFR målt ved iohexol-clearance hos deltagere fra RENIS-T6. RENIS-T6 inkluderer 1627 personer i aldersgruppen 50-62 år, uten kjent diabetes, kardiovaskulær sykdom eller nyresykdom, bosatt i Tromsø. Vi har samlet inn data for fødselsvekt ...

    • Lav inntekt, økonomiske problemer og lavt utdanningsnivå som risiko for utvikling av kronisk smertesyndrom i en norsk befolkning. Helseundersøkelsen i Nord-Trøndelag (HUNT). 

      Løkken, Bente Irene (Mastergradsoppgave; Master thesis, 2011-08-01)
      Bakgrunnen for denne masteroppgaven var at flere i en lavere sosioøkonomisk klasse ser ut til å bli rammet av fibromyalgi, og mye tyder på en økende forekomst. Formålet var å beregne kumulativ insidens over ti år i en norsk befolkning. Analysere om lav inntekt, økonomiske problemer og lavt utdanningsnivå kan ha noen betydning på risiko for å utvikle fibromyalgi. Materiale er hentet fra Helseundersøkelsen ...

    • Lave serumkonsentrasjoner av TGF-β hos nord-norske pasienter med systemisk lupus erythematosus (SLE) og granulomatøs polyangiitt (GPA) 

      Fossmark, Maria Olsen (Master thesis; Mastergradsoppgave, 2017-09-18)
      Innledning: Systemisk lupus erythematosus (SLE) og granulomatøs polyangitt (GPA) er systemiske autoimmune sykdommer. Immunforsvaret tolererer vanligvis egne celler og vev, men toleransen brytes ved autoimmunitet. Ved aktivert immunforsvar vil serumkonsentrasjon av cytokiner, heriblant «transforming growth factor beta» (TGF-β) og «interferon gamma» (IFN-γ), kunne være endret. Formålet med studien var ...

    • Lavrisikofødende kvinner og deres fødselsforløp på fødeavdelingen ved Hammerfest sykehus. 

      Helander, Camilla Hansen (Master thesis; Mastergradsoppgave, 2015-06-01)
      Prinsippet om ”Active management of labour” brukes på fødeinstitusjoner i Norge. Prinsippet går ut på at fødselsfremgangen skal ha en cervixdilatasjon på 1 cm per time. Ved manglende fremgang gjøres tiltak i form av amniotomi eller bruk av oxytocin. Det er av interesse å beskrive den gjennomsnittlige lavrisikofødende kvinnen på en fødeavdeling, samt se om slike tiltak blir utført. En retrospektiv, ...

    • LC-MS basert analysemetode av gentamicin i blodprøver 

      Haug, Marianne Helene Christiansen (Master thesis; Mastergradsoppgave, 2012-05-20)
      Gentamicin er hyppig brukt til å behandle alvorlige infeksjoner, men kan ved langvarig behandling eller ved høy serumkonsentrasjon gi vevsskade i både nyrer og ører. Måling av serumkonsentrasjonen skjer rutinemessig med en immunologisk metode som krever et blodvolum på 500 µl. Hyppige målinger er i noen tilfeller nødvendig for å få god kontroll på behandlingen. Premature barn har lav kroppsvekt og ...

    • LC-MS characterization of pigments in microalgae from different cultivation regimes 

      Stokkeland, Ingunn Møgedal (Master thesis; Mastergradsoppgave, 2019-05-15)
      <p>Background: The Artic University of Norway entered a partnership with a smelting plant to reduce the factory fume CO2-footprint by cultivation of microalgae (diatoms). The biomass produced from the microalgae is rich in lipids, proteins and pigments and can potentially function as fish feed for the aquaculture industry. Before the biomass can be utilized as e.g. fish feed, a thorough investigation ...

    • LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons 

      Kournoutis, Athanasios; Johansen, Terje (Journal article; Tidsskriftartikkel, 2023-04-10)
      It is becoming increasingly clear that the Atg8 family of autophagy proteins have roles not only in the cytoplasm, but also in the cell nucleus. In this issue, Jimenez-Moreno et al. (2023. J. Cell Biol. <a href=https://doi.org/10.1083/jcb.201910133>https://doi.org/10.1083/jcb.201910133</a>) report that nuclear LC3B binds to the LIM homeodomain transcription factor LMX1B and acts as a cofactor for ...

    • LDL apheresis beyond lipid reduction : a study of three different apheresis columns in heterozygous familial hypercholesterolemia and ex vivo 

      Hovland, Anders W. (Doctoral thesis; Doktorgradsavhandling, 2012-06-01)
      When low density lipoprotein (LDL) cholesterol cannot be adequately controlled by medications, it is possible to reduce LDL-cholesterol by means of LDL apheresis. This extracorporeal treatment is most often used in familial hypercholesterolemia (FH). The procedure is known to reduce LDL-cholesterol significantly. Few studies however, have prospectively and systematically examined how different LDL ...

    • LDL-cholesterol goal achievement, cardiovascular disease, and attributed risk of Lp(a)in a large cohort of predominantly genetically verified familial hypercholesterolemia 

      Bogsrud, Martin Prøven; Græsdal, Asgeir; Johansen, Dan; Langslet, Gisle; Hovland, Anders; Arnesen, Kjell Erik; Mundal, Liv; Retterstøl, Kjetil; Wium, Cecilie; Holven, Kirsten Bjørklund (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-30)
      <i>Background</i> - Current treatment goals for familial hypercholesterolemia (FH) recommended by the European Atherosclerosis Society (EAS) are LDL-C ≤2.5 mmol/L (∼100 mg/dL) or ≤1.8 mmol/L (∼70 mg/dL) in very high-risk subjects.<p> <p><i>Objective</i> - The objective of the present study was to investigate characteristics and treatment status in subjects with genetically verified FH followed ...

    • Leadership in rural medicine: The organization on thin ice? 

      Hana, jan; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-04-28)
      Objective. To explore the personal experiences of and conceptions regarding leading rural primary care in Northern Norway. Design. Qualitative content analysis of focus-group interviews. Setting. Lead primary care physicians in the three northernmost counties. Subjects. Four groups with 22 out of 88 municipal lead physicians in the region. Results. Three main categories were developed and bound ...

    • Leadership is the essential non-technical skill in the trauma team : results of a qualitative study 

      Wisborg, Torben; Hjortdahl, Magnus; Ringen, Amund H; Næss, Anne Cathrine Braarud (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
      Background: Trauma is the leading cause of death for young people in Norway. Studies indicate that several of these deaths are avoidable if the patient receives correct initial treatment. The trauma team is responsible for initial hospital treatment of traumatized patients, and team members have previously reported that non-technical skills as communication, leadership and cooperation are the ...