Background Sexual assault and rape are the traumatic life events with the highest probability for posttraumatic stress disorder (PTSD), which can have devastating consequences for those aficted by the condition. Studies indicate that modifed prolonged exposure (mPE) therapy may be efective in preventing the development of PTSD in recently traumatized individuals, and especially for people who ...

Background: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant condition characterized by the appearance of hundreds to thousands of adenomatous polyps throughout the colon and rectum. If the condition is left untreated it will ultimately develop into colorectal cancer. Most of the articles available today concerning FAP focus on the adenomatous polyposis coli gene as this gene ...

Obesity leads to alterations in myocardial metabolism, expressed as an increased utilization of fat for energy purposes at the expense of carbohydrate. This shift in energy metabolism is associated with impairment of ventricular function which can lead to heart failure. This thesis raises the question of whether dietary supplementation with Calanus oil, a novel marine oil derived from the marine ...

Intracellular cyclic nucleotides are eliminated by phosphodiesterases (PDEs) and by ATP Binding cassette transporters such as ABCC4 and ABCC5. PDE5 and ABCC5 have similar affinity for cGMP whereas ABCC5 has much higher affinity for cGMP compared with cAMP. Since the substrate (cGMP) is identical for these two eliminatory processes it is conceivable that various PDE inhibitors also modulate ...

The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes in its microdomain organization. PM microdomains such as lipid rafts, dynamic nanoscale assemblies enriched in cholesterol and sphingomyelin, and ...

Aims: The basis of the study was to evaluate if MIH could be related to low levels of vitamin D. Vitamin D is understood to have a key role in both enamel and dentin formation, and maturation, in addition to skeletal integrity. BMD could give a clue of the participants’ long - term vitamin D exposure, indirectly giving a reflection of a possible vitamin D impact on enamel mineralization. Materials ...

Nydannelse av blodkar er avgjørende for at en kreftsvulst skal etablere seg og vokse og et viktig angrepspunkt for ny kreftbehandling. Arbeidet undersøker molekyler som er viktig for reguleringen av blodkardannelse i kreftsvulster og hvordan disse påvirker overlevelsesprognosen for lungekreftpasienter. <br>Avhandlingens tittel er ”Molecular analysis of angiogenic markers as prognostic factors for ...

The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing worldwide. Here we present associated patient data and molecular, epidemiological and phenotypic characteristics of all CPE isolates in Norway from 2007 to 2014 confirmed at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. All confirmed CPE isolates were characterized pheno- and genotypically, ...

Background: Cowpox virus (CPXV), a rodent-borne Orthopoxvirus (OPV) that is indigenous to Eurasia can infect humans, cattle, felidae and other animals. Molecular characterization of CPXVs isolated from different geographic locations is important for the understanding of their biology, geographic distribution, classification and evolution. Our aim was to characterize CPXVs isolated from Fennoscandia ...

Given the link between the compelling impact of Staphylococcus aureus colonization on the risk and outcome of infection, strategies to prevent nasal colonization could be an appealing method of fighting infection. The ability of S. aureus to colonize and infect a host is a balance between its multitudes of virulence factors and the host immune defence mechanisms. Despite the multiple bacterial factors ...