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    • Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone 

      Li, Ruomei; Bhandari, Sabin; Martinez-Zubiaurre, Inigo; Bruun, Jack-Ansgar; Urbarova, Ilona Halva; Smedsrød, Bård; Simon-Santamaria, Jaione; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-02)
      Introduction<p> <p>Liver sinusoidal endothelial cells (LSECs) are specialized fenestrated scavenger endothelial cells involved in the elimination of modified plasma proteins and tissue turnover waste macromolecules from blood. LSECs also participate in liver immune responses. A challenge when studying LSEC biology is the rapid loss of the in vivo phenotype in culture. In this study, we have ...

    • Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: Potential impact on angiogenesis and tumor growth 

      Hellevik, Turid; Pettersen, Ingvild; Berg, Vivian; Bruun, Jack-Ansgar; Bartnes, Kristian; Busund, Lill-Tove; Chalmers, Anthony; Bremnes, Roy M.; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)
      In the context of radiotherapy, collateral effects of ablative ionizing radiation (AIR) on stromal components of tumors remains understudied. In this work, cancer-associated fibroblasts (CAFs) isolated from freshly resected human lung tumors were exposed to AIR (1x18Gy) and analyzed for their release of paracrine factors. Inflammatory mediators and regulators of angiogenesis and tumor growth were ...

    • Changes in waist circumference and the prevalence of abdominal obesity during 1994-2008 - cross-sectional and longitudinal results from two surveys: the Tromsø Study 

      Jacobsen, Bjarne K.; Aars, Nils Abel (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-21)
      <b>Background:</b> Abdominal obesity increases all-cause mortality and is a risk factor for a number of diseases. There are few population-based studies of the longitudinal changes of abdominal obesity.<br> <b>Methods:</b> Based on data from the Tromsø Study, we studied gender- and age-specific mean waist circumference and prevalence of abdominal overweight and abdominal obesity in two surveys ...

    • The changing alcohol drinking patterns among older adults show that women are closing the gender gap in more frequent drinking: The Tromsø Study, 1994 – 2016 

      Stelander, Line Tegner; Høye, Anne; Bramness, Jørgen Gustav; Selbæk, Geir; Lunde, Linn Heidi; Wynn, Rolf; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)
      Background - As the population of older adults continues to grow, changes in alcohol consumption are important to monitor because an increase may have public health consequences. Rates of alcohol use vary with geographical location. The aim of this study was to examine trends in alcohol consumption among older adults in a geographically defined area in Norway, especially changing sex differences in ...

    • Changing patterns in treatment, remission status, and categories in a long-term Nordic cohort study of juvenile idiopathic arthritis 

      Glerup, Mia; Arnstad, Ellen Dalen; Rypdal, Veronika; Peltoniemi, Suvi; Aalto, Kristiina; Rygg, Marite; Nielsen, Susan; Fasth, Anders; Berntson, Lillemor; Nordal, Ellen Berit; Herlin, Troels (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-10)
      Objective - To explore sustainability of achieved remission off medication and defined International League of Associations for Rheumatology (ILAR) categories in juvenile idiopathic arthritis (JIA) and describe the trajectory of disease course over time by comparing treatment, disease activity, and ILAR categories from baseline, 8 years, and 18 years after disease onset.<p> <p>Methods - A total ...

    • Changing trends in caesarean section births in Murmansk County, Russia 

      Sherkunova, Tatiana (Master thesis; Mastergradsoppgave, 2014-03-09)
      Objective: To analyze changing trends of caesarean section (CS) birth rates in Murmansk County, Russia over a 5- year period (2006-2010) using the Robson 10-group classification system. Design: A registry- based study. Setting: The Murmansk County Birth Registry (MCBR). Study population: All deliveries registered (N=44 267) in the MCBR between 1st of January 2006 and 31st of December 2010. ...

    • Chapter 11 - Hydrogels as intrinsic antimicrobials 

      Vanić, Željka; Skalko-Basnet, Natasa (Chapter; Bokkapittel, 2019-10-25)
      Hydrogels are currently applied as the vehicles for drugs or active substances, rather than the active contributors to therapeutic activities. With increasing challenges related to antimicrobial resistance against many antibiotics, natural origin hydrogels have become attractive as more than just vehicles. Although many natural polymers exhibit intrinsic antimicrobial properties, these properties ...

    • Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma 

      Wirsing, Anna Maria; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-08-23)
      <p><i>Background -</i>Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer, where their presence is found to predict favourable outcome. The purpose of the present study was to evaluate ...

    • Characterisation of parapoxviruses isolated from Norwegian semi-domesticated reindeer (Rangifer tarandus tarandus) 

      Klein, Jörn; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2005-09-05)
      Background: Two outbreaks of the disease contagious ecthyma were reported in 1999 and 2000 in Norwegian semi-domesticated reindeer (Rangifer tarandus tarandus). Contagious ecthyma is an epidermal disease of sheep and goats worldwide, which is caused by the zoonotic parapoxvirus orf virus. Characterisation of clinical samples from the two outbreaks in semi-domesticated reindeer in Norway by ...

    • Characterisation of the Plasmidome within Enterococcus faecalis Isolated from Marginal Periodontitis Patients in Norway 

      Song, Xiaobo; Sun, Jinglu; Mikalsen, Theresa; Roberts, Adam P.; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The present study aimed to identify and characterize plasmids in a national collection of oral Enterococcus faecalis (n = 106) isolated from patients with marginal periodontitis. Plasmid replicon typing was performed by multiplex-PCR and sequencing with specific primers for 18 rep-families and 1 unique sequence. Additional plasmid analysis by S1-PFGE was performed for comparison. Totally 120 plasmid ...

    • Characteristics and outcomes of patients who did not respond to a national spine surgery registry 

      Kaur, Simran; Alhaug, Ole Kristian; Dolatowski, Filip Celestyn; Solberg, Tore; Lønne, Greger (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-04)
      Background Loss to follow-up may bias outcome assessments in medical registries. This cohort study aimed to analyze and compare patients who failed to respond with those that responded to the Norwegian Registry for Spine Surgery (NORspine).<p> <p>Methods We analyzed a cohort of 474 consecutive patients operated for lumbar spinal stenosis at four public hospitals in Norway during a two-year period. ...

    • Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy 

      Torstveit, Ann Helen; Miaskowski, Christine; Løyland, Borghild; Grov, Ellen Karine; Ritchie, Christine Seel; Paul, Steven M; Engh, Anna Marie Ellström; Utne, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-03)
      Purpose Study purposes were to evaluate for inter-individual variability in the trajectories of three objective measures of physical function (PF) in older patients receiving chemotherapy (n=112) and determine which characteristics were associated with worse PF.<p> <p>Methods Balance, gait speed, and chair-stand test were evaluated at initiation and 1, 3, 6, 9, and 12 months following chemotherapy. ...

    • Characteristics of community-based occupational therapy: Results of a Norwegian survey 

      Bonsaksen, Tore; Dolva, Anne-Stine; Horghagen, Sissel; Sveen, Unni; Hagby, Cathrine; Arntzen, Cathrine (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-27)
      <i>Background</i> : Ongoing changes in healthcare delivery systems in Norway increasingly require community-based services, and the changes will likely affect the working conditions and opportunities for occupational therapists. <p> <p><i>Aim</i>: To characterize occupational therapy in community-based practice in Norway. <p> <p><i>Material and methods</i>: A cross-sectional, descriptive ...

    • The characteristics of general practice and the attractiveness of working as a GP: medical students´ views 

      Landström, Björn; Mattsson, Bengt; Nordin, Per; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals 

      Howe, Anita Y.M.; Rodrigo, Chaturaka; Cunningham, Evan B.; Douglas, Mark W.; Dietz, Julia; Grebely, Jason; Popping, Stephanie; Sfalcin, Javier Alejandro; Parczewski, Milosz; Sarrazin, Christoph; de Salazar, Adolfo; Fuentes, Ana; Sayan, Murat; Quer, Josep; Kjellin, Midori; Kileng, Hege; Mor, Orna; Lennerstrand, Johan; Fourati, Slim; Di Maio, Velia Chiara; Chulanov, Vladimir; Pawlotsky, Jean-Michel; Harrigan, P. Richard; Ceccherini-Silberstein, Francesca; Garcia, Federico (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)
      Background & Aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and ...

    • Characteristics of Patients Who Complete Suicide and Suicide Attempts While Undergoing Treatment in Norway: Findings from Compensation Claims Records 

      Krvavac, Sanja; Bystad, Martin Kragnes; Wynn, Rolf; Bukholm, Ida Rashida Khan; Jansson, Billy (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-24)
      The aim of this study was to identify characteristics that differentiate patients who complete suicide (SC) from patients with suicide attempts (SA) while undergoing treatment in Norway. We examined data from the Norwegian System of Patient Injury Compensation (Norsk Pasientskade Erstatning—NPE). Data were extracted from NPE case records from a 10-year period (2009–2019) for 356 individuals who ...

    • Characteristics of successfully implemented telemedical applications 

      Engeseth, Kjersti H.; Obstfelder, Aud; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-07-27)
      Background: There has been an increased interest in the use of telemedical applications in clinical practice in recent years. Considerable effort has been invested in trials and experimental services. Yet, surprisingly few applications have continued beyond the research and development phase. The aim of this study is to explore characteristics of successfully implemented telemedical applications. ...

    • Characteristics of urban neighbourhood environments and cognitive age in mid-age and older adults 

      Soloveva, Maria V.; Poudel, Govinda; Barnett, Anthony; Shaw, Jonathan E.; Martino, Erika; Knibbs, Luke D.; Anstey, Kaarin J.; Cerin, Ester (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-12)
      In this cross-sectional study, we examined the extent to which features of the neighbourhood natural, built, and socio-economic environments were related to cognitive age in adults (N = 3418, Mage = 61 years) in Australia. Machine learning estimated an individual's cognitive age from assessments of processing speed, verbal memory, premorbid intelligence. A ’cognitive age gap’ was calculated by ...

    • Characteristics of women with chronic pelvic pain referred to physiotherapy treatment after multidisciplinary assessment: a cross-sectional study 

      Nygaard, Ane Sigrid; Stedenfeldt, Mona; Øian, Pål; Haugstad, Gro Killi (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-31)
      <i>Background and aims</i> - Chronic pelvic pain (CPP) in women is a complex condition that can seriously impact health and quality of life. Clinical guidelines for CPP place great demands on healthcare professionals, as they require both specialized knowledge about the pelvic area and knowledge of the mechanisms of chronic pain. To ensure best possible assessment and treatment of these women it ...

    • A characterization and comparison of the microRNA expression profile in breast cancer cell lines and exosomes 

      Nikolaisen, Marlen Aas (Master thesis; Mastergradsoppgave, 2013-05-20)
      Breast cancer is the leading cause in cancer deaths among woman worldwide, and one in ten women will experience the disease during their lifetime. Breast cancer accounted for 23% of the total new cancer incidences and 14% of the total cancer deaths in Norway in 2008. One way to potentially improve long-term cancer survival statistics is earlier detection. That includes the discovery and characterization ...