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Characterization of BRCA1 and BRCA2 variants found in a Norwegian breast or ovarian cancer cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-05)Germline mutations in BRCA1 and BRCA2 cause hereditary breast and ovarian cancer. Molecular screening of these two genes in patients with a family history of breast or ovarian cancer has revealed pathogenic variants as well as genetic variants of unknown significance (VUS). These VUS may cause a challenge in the genetic counseling process regarding clinical management of the patient and the family. ... -
Characterization of commensal enterococcal membrane vesicles and their cytotoxic effect on various host cells
(Mastergradsoppgave; Master thesis, 2020-05-14)Enterococcus are a group of bacteria growing on different environmental condition behaving as a commensal as well as opportunistic pathogen. Among the enterococci, Enterococcus faecium is recently emerged as a nosocomial multi-resistance pathogen especially in the severely ill and immunocompromised patients causing a wide range of diseases like endocarditis, bacteraemia and urinary tract infections. ... -
Characterization of competition between commensal and clinical strains of Enterococcus faecium
(Master thesis; Mastergradsoppgave, 2021-06-01)Invasive infection by multidrug-resistant Enterococcus faecium is increasingly becoming a healthcare concern. Few studies have addressed whether and how clinical E. faecium strains are able to outcompete commensal strains. This thesis aimed to characterize the in vitro competition between commensal and clinical E. faecium strains with respect to growth inhibition exerted by bacteriocins produced by ... -
Characterization of extracellular polymeric matrix, and treatment of Fusobacterium nucleatum and Porphyromonas gingivalis biofilms with DNase I and proteinase K
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: Biofilms are organized communities of microorganisms embedded in a self-produced extracellular polymeric matrix (EPM), often with great phylogenetic variety. Bacteria in the subgingival biofilm are key factors that cause periodontal diseases; among these are the Gram-negative bacteria Fusobacterium nucleatum and Porphyromonas gingivalis. The objectives of this study were to characterize ... -
Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-20)Excessive alcohol intake can alter the gut microbiota, which may underlie the pathophysiology of alcohol-related diseases. We examined gut microbiota composition and functions in patients with alcohol overconsumption for >10 years, compared to a control group of patients with a history of no or low alcohol intake. Faecal microbiota composition was assessed by 16S rRNA sequencing. Gut microbiota ... -
Characterization of heavy users of skin care products among Norwegian women from 2003 to 2011
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-16)Background: Several ingredients in personal care products (PCPs) have been classified as endocrine disruptors (EDs) and concern has been raised whether use of PCPs can affect human health. We aimed to characterize Norwegian female users of skin care products and compare life style characteristics between heavy users and non-users. <p>Methods: This cross-sectional study consisted of 114 202 women ... -
Characterization of inhibition by vardenafil analogues of ATP-dependent transport of cGMP by the ABCC5 transporter.
(Master thesis; Mastergradsoppgave, 2015-05-27)Background: Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports intracellular cGMP out of the cells with high affinity, while PDE5 inhibitors prevent high affinity cGMP efflux by inhibiting ABCC5. Increasing intracellular cGMP levels through inhibition of PDE5 and PDE5 export activity is hypothesized ... -
Characterization of Liposomes Using Quantitative Phase Microscopy (QPM)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-21)The rapid development of nanomedicine and drug delivery systems calls for new and effective characterization techniques that can accurately characterize both the properties and the behavior of nanosystems. Standard methods such as dynamic light scattering (DLS) and fluorescent-based assays present challenges in terms of system’s instability, machine sensitivity, and loss of tracking ability, among ... -
Characterization of mitochondrial mRNAs in codfish reveals unique features compared to mammals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Expression and processing of mitochondrial gene transcripts are fundamental to mitochondrial function, but information from early vertebrates like teleost fishes is essentially lacking. We have analyzed mitogenome sequences of ten codfishes (family Gadidae), and provide complete sequences from three new species (Saithe, Pollack and Blue whiting). Characterization of the mitochondrial mRNAs in Saithe ... -
Characterization of Norwegian women eating wholegrain bread
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-25)To investigate dietary and non-dietary characteristics of wholegrain bread eaters in the Norwegian Women and Cancer study.<br>Cross-sectional study using an FFQ.<br>Women were divided into two groups according to wholegrain bread consumption.<br>Adult women (n 69 471).<br>Median daily consumption of standardized slices of wholegrain bread was 2·5 in the low intake group and 4·5 in the high intake ... -
Characterization of novel precursor miRNAs using next generation sequencing and prediction of miRNA targets in Atlantic halibut
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)microRNAs (miRNAs) are implicated in regulation of many cellular processes. miRNAs are processed to their mature functional form in a step-wise manner by multiple proteins and cofactors in the nucleus and cytoplasm. Many miRNAs are conserved across vertebrates. Mature miRNAs have recently been characterized in Atlantic halibut (Hippoglossus hippoglossus L.). The aim of this study was to identify and ... -
Characterization of the Arabidopsis thaliana homologue of NBR1
(Master thesis; Mastergradsoppgave, 2009-05-15)It is now well established that p62 and NBR1 are selectively degraded by autophagy and can act as cargo receptors or adaptors for the autophagic degradation of ubiquitinated substrates. Research on autophagy in plants is also well under way, but the mechanism by which target substrates are sequestered for autophagic degradation has not been elucidated. The uncharacterized plant protein Q9SB64 shares ... -
Characterization of the cell secretomes from undifferentiated and chondro-induced stem cells
(Master thesis; Mastergradsoppgave, 2015-05-20)Background: Articular cartilage is an essential part of the skeletal system. It provides a frictionless surface for smooth pain-free articulation and limits the load applied to subchondral bone during joint movement. Articular cartilage is an avascular and aneural tissue without lymphatic vessels. Due to this unique nature, articular cartilage has poor self-repair capacity. Therefore, minor cartilage ... -
Characterization of the degree of food processing in the European Prospective Investigation into Cancer and Nutrition: Application of the Nova classification and validation using selected biomarkers of food processing
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-16)Background: Epidemiological studies have demonstrated an association between the degree of food processing in our diet and the risk of various chronic diseases. Much of this evidence is based on the international Nova classification system, which classifies food into four groups based on the type of processing: (1) Unprocessed and minimally processed foods, (2) Processed culinary ingredients, ... -
Characterization of the Ion Exchange Reaction Between Propranolol-H+ or K+ with Amberlite IRP 69 Resin by Both, Isothermal Titration Calorimetry and (Flame) Photometric Equilibrium Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009) -
Characterization of vasskveite (water halibut) syndrome for automated detection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-23)In recent years, cases of vasskveite (water halibut) syndrome in halibut have been increasing. At the moment, there exists no way to screen for the syndrome immediately after capture, which is problematic for both exporters and purchasers. In this article, we compared good quality halibut and halibut exhibiting the syndrome using a variety of techniques. Hyperspectral imaging was used to quantify ... -
Charcot-Marie-Tooth disease (CMT): statistical analysis and revision of molecular genetic diagnostics in a patient population and identification of the disease locus in a large Norwegian family with CMT.
(Doctoral thesis; Doktorgradsavhandling, 2014-09-19)CMT is a common inherited disease of the peripheral nerves that may be caused by mutations in multiple genes, most are rare. Our aim was to describe the spectrum of mutations and genes in Norwegian CMT patients, identify factors associated with diagnostic findings, revise the testprotocol, and evaluate the assessments of genetic variants of uncertain clinical significance. Furthermore, we searched ... -
CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-26)Background Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis or global gene expression profiles have failed to identify mechanisms causing in vivo resistance to anthracyclines. While we previously found TP53 mutations in the L2/L3 domains to ... -
Chemical and Enzyme-Assisted Extraction of Fucoidan from two Species of Brown Macroalgae (Ascophyllum nodosum and Saccharina latissima)
(Conference object; Konferansebidrag, 2022)Macroalgae are vital species and are known to produce a wide range of bioactive compounds including polysaccharides, such as fucoidan. Traditionally, these compounds are extracted using hazardous solvents that leads to environmental pollution and waste. Considering this, more sustainable technologies are being investigated as greener alternatives.<p> <p>The main goal of this study was to ... -
The chemotherapeutic drug methotrexate selects for antibiotic resistance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-11)Background: Understanding drivers of antibiotic resistance evolution is fundamental for designing optimal treatment strategies and interventions to reduce the spread of antibiotic resistance. Various cytotoxic drugs used in cancer chemotherapy have antibacterial properties, but how bacterial populations are affected by these selective pressures is unknown. Here we test the hypothesis that the widely ...
