Due to its peculiar histopathological findings, pleomorphic xanthoastrocytoma (PXA), a rare cerebral tumor of young adults with a slow growth and a good prognosis, resembles to the lytic phase of progressive multifocal leukoencephalopathy, a fatal neurodegenerative disease caused by JC polyomavirus (JCPyV). Therefore, the presence of JCPyV DNA was examined in an 11-year-old child with xanthoastrocytoma, ...

Merkel cell polyomavirus (MCPyV) is the etiological agent of the majority of Merkel cell carcinoma (MCC): a rare skin tumor. To improve our understanding of the role of MCPyV in MCCs, the detection and analysis of MCPyV DNA and transcripts were performed on primary tumors and regional lymph nodes from two MCC patients: one metastatic and one non-metastatic. MCPyV-DNA was searched by a quantitative ...

<i>Objectives</i> - Antimicrobial resistance (AMR) in clinically relevant bacteria is a growing threat to public health globally. In these bacteria, antimicrobial resistance genes are often associated with mobile genetic elements (MGEs), which promote their mobility, enabling them to rapidly spread throughout a bacterial community.<p> <i>Methods</i> - The tool MobileElementFinder was developed ...

Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used isogenic human breast epithelial cell lines, D492 and D492M, representing the epithelial and mesenchymal phenotypes, respectively. We employed a CRISPR-Cas9 ...

Tissue factor (TF) is the most important trigger for the extrinsic coagulation pathway. TF, earlier denoted as thromboplastin, has always been a mystery since its discovery due to its abundant presence in most human tissues but not blood. The latter has been extensively studied in a vast quest for possible sources of blood-borne TF yielding many conflicting findings and confusing conclusions regarding ...

Bakgrunn. 20-30% av pasienter med cancer mamma har overuttrykk av HER2 reseptoren (Human Epidermal growth factor Receptor) på overflaten av tumorcellene. HER2-postiv cancer mamma er assosiert med økt tumorvekst, økt metastasering og dårligere prognose. Immunhistokjemi (IHC) og FISH (Fluorescence in situ hybridization) på formalinfiksert parafin innstøpt (FFPE) materiale er de mest brukte metodene ...

Background: Breast cancer is the most frequent cancer among women worldwide, and the second most important cause of cancer death in developed countries after lung cancer. Early detection with mammographic screening reduces breast cancer mortality. Few studies have investigated factors associated with participation in The Norwegian Breast Cancer Screening Programme. Objective: To identify determinants ...

Abstract PURPOSE: To study conventional and novel risk factors associated with high cardiovascular disease (CVD) and all-cause mortality in Russia. METHODS: A prospective cohort study of 3704 adults was performed in Arkhangelsk. The baseline examination was conducted in 1999-2000. The average follow-up was 10.2 years. Information on lifestyle and marital, educational, and psychosocial status was ...

Objective:<br> To describe the determinants of 12‐year weight change among middle‐aged women in Sweden. <br>Methods:<br> In 1991/1992, 49,259 women across Sweden were recruited into a cohort. In 2003, 34,402 (73%) completed follow‐up. Lifestyle and health characteristics including weight were collected, and 12‐year weight change and substantial weight gain (≥+5.0 kg) were calculated; association ...

Staphylococcus aureus is an efficient human colonizer and pathogen. S.aureus' ability to colonize and/or cause infections in humans is due to its expression of many virulence factors. These virulence factors aid the bacterium in adhering, invading and evading the host´s immune defences. This study focused on exploring the role of two cell wall anchored proteins: Serine-aspartate containing protein ...