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norskBlar i tittel Det helsevitenskapelige fakultet
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Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-04)<b>Background</b> Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral ... -
Development and validation of a simple online-SPE method coupled to high-resolution mass spectrometry for the analysis of stanozolol-N-glucuronides in urine samples
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-17)Stanozolol is still the most commonly used illicit anabolic‐androgenic steroid (AAS) in professional sports. Therefore, accurate and fast analysis and long detection windows are of great interest in the field of antidoping analysis. In this work, a very simple, fast, and highly sensitive online solid‐phase extraction method coupled with liquid chromatography–high‐resolution tandem mass spectrometry ... -
Development and validation of an instrument to assess oral health literacy in Norwegian adult dental patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-05)Objective: To develop and validate an interview instrument to assess oral health literacy in Norwegian adult dental patients. <p/>Materials and methods: The instrument, Adult Health Literacy Instrument for Dentistry (AHLID), was based on an OECD instrument used to assess general literacy in adults. 130 Norwegian adults (mean age 48 years; 57% women) participated. AHLID included a selection of ... -
Development and validation of circulating CA125 prediction models in postmenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-26)<i>Background</i> - Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.<p><p> <i>Methods</i> - We developed and validated ... -
Development and validation of the Efficacy Safety Score (ESS), a novel tool for postoperative patient management
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-28)Background: <br> Several reports have shown that postoperative monitoring of general safety and quality issues, including pain treatment, after discharge from recovery is often non-systematic and inadequate. We suggest a new score with assessment of key recovery parameters, as a supportive tool for postoperative care and a call-out algorithm for need of extra help. The aim of this investigation ... -
The development journey of an artificial intestinal model predicting oral drug absorption: the mucus-PVPA model
(Doctoral thesis; Doktorgradsavhandling, 2021-04-23)Oral drug administration is the most convenient route to systemically deliver drugs because of its cost-effectiveness, ease of administration and high patient compliance. However, when a drug is orally administered it will be exposed to the different physiological processes and environments found along the gastrointestinal (GI) tract, which will determine its ability of being absorbed and reach the ... -
Development of 8f-labeled radiotracers for pet imaging of the adenosine a2a receptor: Synthesis, radiolabeling and preliminary biological evaluation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A<sub>2A</sub>R-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ... -
Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Development of a Clinical Scandinavian Registry for Hidradenitis Suppurativa; HISREG
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Hidradenitis suppurativa (HS; or acne inversa) is a scarring and frequently persistent inflammatory disorder of the terminal hair follicles of apocrine gland-bearing skin in adults. Treatments include local or systemic antibiotics, hormones, retinoids and systemic immunosuppressive agents (1), although on evaluation these have been shown to have only limited or temporary effect. In refractory cases, ... -
Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-16)Objective: To develop and validate a responsive and feasible ultrasound inflammation score for rheumatoid arthritis (RA). Methods: We used data from cohorts of early RA (development) and established RA starting/switching biologic therapy (validation). 4 tendons and 36 joints were examined by a grey scale (GSUS) and power Doppler semiquantitative ultrasound (PDUS) scoring system (full score). ... -
Development of a homologous gene replacement approach to study ciprofloxacin resistance in clinical Escherichia coli isolates
(Master thesis; Mastergradsoppgave, 2017-05-15)Urinary tract infections are common amongst infectious diseases in humans, and often these infections are caused by uropathogenic Escherichia coli. Effective antimicrobial treatment of infections are medical achievements that should not be taken for granted, as antimicrobial resistance has developed and causes treatments to become ineffective. Further, resistance traits can be spread between unrelated ... -
The development of a multilingual tool for facilitating the primary-specialty care interface in low resource settings: the MSF tele-expertise system
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)In 2009, Médecins Sans Frontières (MSF) started a pilot trial of store-and-forward telemedicine to support field workers. One network was operated in French and one in English; a third, Spanish network was brought into operation in 2012. The three telemedicine pilots were then combined to form a single multilingual tele-expertise system, tailored to support MSF field staff. We conducted a retrospective ... -
Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing efficacy in a db/db diabetic mouse model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-30)To relieve the severe economic and social burdens and patient suffering caused by the increasing incidence of chronic wounds, more effective treatments are urgently needed. In this study, we focused on developing a novel sprayable wound dressing with the active ingredient β-1,3/1,6-glucan (βG). Since βG is already available as the active ingredient in a commercial wound healing product provided as ... -
The Development of a pharmaceutical care plan in the Scottish mental health service
(Master thesis; Mastergradsoppgave, 2008-06)Abstract Background Pharmaceutical care planning is increasingly seen as the most effective manner by which to deliver pharmaceutical care services to the patient. The role of the pharmacist, both specialist and generalist, is paramount, as much of the treatment in Mental Health is dependent on the effective management of the patients medication(1). Consequently, there is a need for standardised ... -
Development of a prognostic model for unfavorable outcome after lumbar microdiscectomy
(Doctoral thesis; Doktorgradsavhandling, 2021-05-11)The aim of this thesis was to develop a prognostic model for unfavorable outcome 12 months after surgical treatment of a lumbar disc herniation (lumbar microdiscectomy). While the surgical procedure is rather uniform, with little technical variation, the reported outcomes are quite heterogenous. This might be due to different expectations by patients, or due to suboptimal surgical indication as ... -
Development of a Score Predicting Survival after Palliative Reirradiation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
The development of a tool to assess medical students’ non-technical skills–The Norwegian medical students’ non-technical skills (NorMS-NTS)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)Purpose - New physicians need to master non-technical skills (NTS), as high levels of NTS have been shown to increase patient safety. It has also been shown that NTS can be improved through training. This study aimed to establish the necessary NTS for Norwegian medical students to create a tool for formative and summative assessments.<p> <p>Methods - Focus group interviews were conducted with ... -
Development of an analytical method for detection and quantification of cannabis and cannabinoid analogues in urine
(Master thesis; Mastergradsoppgave, 2010-05-20)Cannabis is a drug mainly consumed for its euphoric effects; users may become happy, careless and relaxed. The direct effects of cannabis in sports are performance decreasing, but cannabis can be used as a doping agent due to its relaxing properties. For these reasons, cannabinoids are prohibited in sports during competition by the World Anti-Doping Agency (WADA). In the context of the fight ... -
Development of an assay for determining PDE5 enzyme activity and for screening of potential inhibitors of the PDE5 enzyme in cancer cells
(Master thesis; Mastergradsoppgave, 2013-05-15)PDE5 is a member of the superfamily of phosphodiesterases, and it is identified as the main mechanism for breakdown of cGMP in mammals. Sildenafil is a well-known inhibitor of the PDE5 enzyme and it is also shown that sildenafil inhibits the ABCC5 transporter pump. ABCC5 is a member of the superfamily of ABC-transporters, and identified as an important transporter for mediating the cellular efflux ... -
Development of an in vitro model to study compromised skin: pigskin versus the Phospholipid Vesicle-based Permeation Assay
(Master thesis; Mastergradsoppgave, 2013-05-20)When the skin barrier is reduced, penetration of topical and transdermal drugs could potentially be enhanced and the risk of systemic effects is increased. The studies analysing penetration through intact or diseased skin are often limited by the variability in obtaining specimens of representative skin. The phospholipid vesicle-based permeation assay is an artificial barrier mimicking human stratum ...
