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norskBlar i tittel Det helsevitenskapelige fakultet
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Development of 8f-labeled radiotracers for pet imaging of the adenosine a2a receptor: Synthesis, radiolabeling and preliminary biological evaluation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A<sub>2A</sub>R-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ... -
Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Development of a Clinical Scandinavian Registry for Hidradenitis Suppurativa; HISREG
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Hidradenitis suppurativa (HS; or acne inversa) is a scarring and frequently persistent inflammatory disorder of the terminal hair follicles of apocrine gland-bearing skin in adults. Treatments include local or systemic antibiotics, hormones, retinoids and systemic immunosuppressive agents (1), although on evaluation these have been shown to have only limited or temporary effect. In refractory cases, ... -
Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-16)Objective: To develop and validate a responsive and feasible ultrasound inflammation score for rheumatoid arthritis (RA). Methods: We used data from cohorts of early RA (development) and established RA starting/switching biologic therapy (validation). 4 tendons and 36 joints were examined by a grey scale (GSUS) and power Doppler semiquantitative ultrasound (PDUS) scoring system (full score). ... -
Development of a homologous gene replacement approach to study ciprofloxacin resistance in clinical Escherichia coli isolates
(Master thesis; Mastergradsoppgave, 2017-05-15)Urinary tract infections are common amongst infectious diseases in humans, and often these infections are caused by uropathogenic Escherichia coli. Effective antimicrobial treatment of infections are medical achievements that should not be taken for granted, as antimicrobial resistance has developed and causes treatments to become ineffective. Further, resistance traits can be spread between unrelated ... -
The development of a multilingual tool for facilitating the primary-specialty care interface in low resource settings: the MSF tele-expertise system
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)In 2009, Médecins Sans Frontières (MSF) started a pilot trial of store-and-forward telemedicine to support field workers. One network was operated in French and one in English; a third, Spanish network was brought into operation in 2012. The three telemedicine pilots were then combined to form a single multilingual tele-expertise system, tailored to support MSF field staff. We conducted a retrospective ... -
Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing efficacy in a db/db diabetic mouse model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-30)To relieve the severe economic and social burdens and patient suffering caused by the increasing incidence of chronic wounds, more effective treatments are urgently needed. In this study, we focused on developing a novel sprayable wound dressing with the active ingredient β-1,3/1,6-glucan (βG). Since βG is already available as the active ingredient in a commercial wound healing product provided as ... -
The Development of a pharmaceutical care plan in the Scottish mental health service
(Master thesis; Mastergradsoppgave, 2008-06)Abstract Background Pharmaceutical care planning is increasingly seen as the most effective manner by which to deliver pharmaceutical care services to the patient. The role of the pharmacist, both specialist and generalist, is paramount, as much of the treatment in Mental Health is dependent on the effective management of the patients medication(1). Consequently, there is a need for standardised ... -
Development of a prognostic model for unfavorable outcome after lumbar microdiscectomy
(Doctoral thesis; Doktorgradsavhandling, 2021-05-11)The aim of this thesis was to develop a prognostic model for unfavorable outcome 12 months after surgical treatment of a lumbar disc herniation (lumbar microdiscectomy). While the surgical procedure is rather uniform, with little technical variation, the reported outcomes are quite heterogenous. This might be due to different expectations by patients, or due to suboptimal surgical indication as ... -
Development of a Score Predicting Survival after Palliative Reirradiation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
The development of a tool to assess medical students’ non-technical skills–The Norwegian medical students’ non-technical skills (NorMS-NTS)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)Purpose - New physicians need to master non-technical skills (NTS), as high levels of NTS have been shown to increase patient safety. It has also been shown that NTS can be improved through training. This study aimed to establish the necessary NTS for Norwegian medical students to create a tool for formative and summative assessments.<p> <p>Methods - Focus group interviews were conducted with ... -
Development of an analytical method for detection and quantification of cannabis and cannabinoid analogues in urine
(Master thesis; Mastergradsoppgave, 2010-05-20)Cannabis is a drug mainly consumed for its euphoric effects; users may become happy, careless and relaxed. The direct effects of cannabis in sports are performance decreasing, but cannabis can be used as a doping agent due to its relaxing properties. For these reasons, cannabinoids are prohibited in sports during competition by the World Anti-Doping Agency (WADA). In the context of the fight ... -
Development of an assay for determining PDE5 enzyme activity and for screening of potential inhibitors of the PDE5 enzyme in cancer cells
(Master thesis; Mastergradsoppgave, 2013-05-15)PDE5 is a member of the superfamily of phosphodiesterases, and it is identified as the main mechanism for breakdown of cGMP in mammals. Sildenafil is a well-known inhibitor of the PDE5 enzyme and it is also shown that sildenafil inhibits the ABCC5 transporter pump. ABCC5 is a member of the superfamily of ABC-transporters, and identified as an important transporter for mediating the cellular efflux ... -
Development of an in vitro model to study compromised skin: pigskin versus the Phospholipid Vesicle-based Permeation Assay
(Master thesis; Mastergradsoppgave, 2013-05-20)When the skin barrier is reduced, penetration of topical and transdermal drugs could potentially be enhanced and the risk of systemic effects is increased. The studies analysing penetration through intact or diseased skin are often limited by the variability in obtaining specimens of representative skin. The phospholipid vesicle-based permeation assay is an artificial barrier mimicking human stratum ... -
Development of bioactive peptides from the parasitic hookworm as potential treatments for autoimmune diseases
(Master thesis; Mastergradsoppgave, 2012-06)Hookworms are parasitic nematodes that reside in the intestines of their host, where they feed on host blood. The large number of infected individuals and the long survival time inside the host makes it interesting to study the immunomodulatory activities of the hookworms. The excretory/secretory (ES) products are suspected to be responsible for these effects. One aim of this project was to fractionate ... -
Development of biomimetic phospholipid vesicle-based permeation assays (PVPA) as screening tool in drug development
(Doctoral thesis; Doktorgradsavhandling, 2015-04-17)Although several routes of administration can be utilized to bring a drug to the desired site of action, oral administration is still the most important and prevalent route of administration, due to its cost efficiency, convenience and patient compliance. A prerequisite for successful oral therapy is the ability of a drug to cross the gastrointestinal barrier. Over the past two decades, the ... -
Development of chitosan-coated liposomes for improved therapy of vaginal infections: clotrimazole as model drug
(Master thesis; Mastergradsoppgave, 2012-05)For many drugs the vaginal route of administration is favorable, particularly for local therapy of specific gynecological diseases such as vaginal infections. A large variety of pharmaceutical preparations have been developed for vaginal delivery, nevertheless, the efficiency of currently available dosage forms is often limited by their poor retention time at the vaginal site. Physiological changes ... -
Development of COFRADIC HPLC system for proteomics. Sorting of N-terminal peptides
(Master thesis; Mastergradsoppgave, 2014-05-20)Proteomics, the study of the proteins constituting the proteome, has featured in the past few years as an essential tool in a number of diverse areas of therapeutic research for detection of the initial stage of a disease, for consideration of therapy response and for disintegrating fundamental pathophysiological mechanisms. Proteomics has a wide range of applications such as diabetes research, ... -
Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-13)Background - Gestational age (GA) and associated level of gastrointestinal tract maturation are major factors driving the initial gut microbiota composition in preterm infants. Besides, compared to term infants, premature infants often receive antibiotics to treat infections and probiotics to restore optimal gut microbiota. How GA, antibiotics, and probiotics modulate the microbiota’s core ... -
The development of electrospun chloramphenicol containing wound dressing
(Master thesis; Mastergradsoppgave, 2021-05-11)Wound healing is among the most complex processes in the human body that is greatly coordinated with a focus to rebuild tissue integrity and restore the skin´s protective barrier. The normal healing process is disrupted in chronic wounds, leading to delayed wound healing due to several underlying factors such as aging, obesity, and diabetes. Among chronic wounds 50 % are infected and up to 78 % of ...
