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Harnessing Innate Immunity - Complement and TLR Inhibition in Experimental Models of Gram Positive and Polymicrobial Bacteremia and Sepsis
(Doctoral thesis; Doktorgradsavhandling, 2017-11-28)Sepsis is a syndrome of life-threatening organ malfunction caused by a dysregulated host response to infection. The complement, kallikrein/kinin, coagulation and fibrinolysis plasma cascade systems as well as the TLR system recognize and initiate the immediate responses to infection and thus play an important role in the development of sepsis. In this regard, the ubiquitous TLR co-receptor, CD14, ... -
The Harstad injury prevention study : hospital-based injury recording and community-based intervention
(Doctoral thesis; Doktorgradsavhandling, 1995)Accidental injury is the leading cause of death in Norway under the age of 50. A 19 % reduction of age standardized accident mortality was observed from 1956 to 1983. In spite of this, next to Finland, Norway has the highest accident mortality rate among the Nordic countries (1) . To reduce accidental injury it is important to gain knowledge about all injuries, not only the fatal ones. The ... -
Have Changes in Systemic Treatment Improved Survival in Patients with Breast Cancer Metastatic to the Brain?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-07-16)Newly developed systemic treatment regimens might lead to improved survival also in the subgroup of breast cancer patients that harbour brain metastases. In order to examine this hypothesis, a matched pairs analysis was performed that involved one group of patients, which were treated after these new drugs were introduced, and one group of patients, which were treated approximately 10 years earlier. ... -
Have medical students’ attitudes towards clinical communication skills changed over a 12- year period? A comparative long-term study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-10)<i>Background</i> - Attitudes towards learning clinical communication skills at the end of medical school are likely to reflect the students’ training and motivation for the continued development of their skills as doctors. Students from two Norwegian medical schools, one with a traditional, and the other with an integrated curriculum, were approached in 2003 and 2015; with regard to changes in ... -
Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-29)Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk assessment, particularly the characterization of potential adverse effects to humans, ... -
Hazardous alcohol consumption and problem drinking in Norwegian and Russian women and men: The Tromsø Study 2015–2016 and the Know Your Heart study 2015–2018
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-30)Aim: Harmful use of alcohol is a worldwide public health concern. Cultural differences may affect responses to questions on alcohol problems, making international comparisons difficult. We aimed to compare self-reported alcohol consumption and problem drinking between Norwegian and Russian populations.<p> <p>Methods: We used data from women and men aged 40–69 years participating in the Tromsø ... -
Hazardous Alcohol Use and Insomnia in women and men: Insights from the population-based Tromsø Study 2015-2016.
(Mastergradsoppgave; Master thesis, 2021-03-23)Background and aims: Hazardous alcohol use is known to be comorbid with insomnia. The aim of this study was to estimate the prevalence of co-occurring hazardous alcohol use and insomnia symptoms, and the odds of insomnia among women and men with a hazardous alcohol use, using logistic regression and covariate-adjusted moderation analysis. Design setting: Cross-sectional data from the seventh survey ... -
The hazards of death by smoking in middle-aged women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Recent studies have found that the risk of death continues to increase among female smokers, as compared with women who have never smoked. We wanted to examine the effect of smoking on all-cause and causespecific mortality and calculate the corresponding population attributable fraction (PAF) of mortality in the Norwegian women and cancer study; a nationally representative prospective cohort ... -
Hälsorisker vid snusbruk
(Master thesis; Mastergradsoppgave, 2008-06-15)Bakgrund: Det råder oenighet bland forskare när det gäller snusets effekt på hälsan. Fem översiktsrapporter, där man ser på skadepåverkningen av snus, har publicerats och den epidemiologiska forskningen har tolkats på olika sätt. Metod: En systematisk identifisering av litteratur och kritisk värdering av de epidemiologiska studier som har inkluderats i översiktsrapporterna om snusets hälsoeffek ... -
Håndskader hos fiskere
(Master thesis; Mastergradsoppgave, 2004-09) -
Håndskader i yrkeslivet, grad av innrapportering til Arbeidstilsynet
(Master thesis; Mastergradsoppgave, 2002-09) -
Håndtering av ikke-somatisk sykdom i allmennpraksis
(Master thesis; Mastergradsoppgave, 2016-05-31)Sammendrag Formål: Undersøkelse av hvordan allmennleger håndterer pasienter med ikke-somatisk problemstilling i klinisk praksis. Design: Dette er en kvalitativ undersøkelse med deltakende observasjon i allmennpraksis. Setting: 2 allmennleger på samme legekontor, «Jonas» og «Nina» ble observert under konsultasjoner. Legene var ulike med henblikk på alder, kjønn og erfaring. Metode: 34 ulike ... -
Håp og livsmot i sykdomsfortellinger etter hjerneslag
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)This essay illuminates the meaning of hope and life courage in the narratives of Tomas and Maria, a couple who had experienced the life changing consequences of Maria’s stroke. Hope is supported by the couple’s strong and loving relationship and by empathy and caring in their relationships with professional caregivers. In this way, the relational component of hope is revealed as the most important ... -
HbA1c endring over tid hos type 2-diabetikere ved Rønvik legesenter. En retrospektiv oppfølgingsstudie
(Master thesis; Mastergradsoppgave, 2006-09-13) -
HbA1c hos barn med type 1 diabetes mellitus i Troms
(Master thesis; Mastergradsoppgave, 2023-05-25)Type 1 diabetes mellitus (T1D) er en kronisk sykdom som karakteriseres av høy blodglukose og andre metabolske forstyrrelser som skyldes en absolutt eller delvis mangel på produksjon av hormonet insulin. Dette er den vanligste typen diabetes hos barn. Barn og ungdom med T1D følges opp med kontroller av barnelege og diabetessykepleier flere ganger per år. HbA1c er en av de viktigste biokjemiske markørene ... -
HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confoundersin a meta-analysis of individual participant data from six cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-11)Background:<br>To determine the shape of the associations of HbA1c with mortality and cardiovascular outcomes in non-diabetic individuals and explore potential explanations.<br> Methods:<br> The associations of HbA1c with all-cause mortality, cardiovascular mortality and primary cardiovascular events (myocardial infarction or stroke) were assessed in non-diabetic subjects ≥50 years from six ... -
HbA1c som diagnostisk kriterium for diabetes type 2
(Research report; Forskningsrapport, 2013)<b>Hovedbudskap</b> <p>I denne hurtigoversikten har vi formidlet og kvalitetsvurdert to systematiske oversikter som er benyttet som dokumentasjonsgrunnlag for to anbefalinger. Den ene er Verdens helseorganisasjon (WHO) sin anbefaling fra 2011 vedrørende HbA1c som diagnostisk kriterium for diabetes, og den andre er National Institute for Health and Care Excellence (NICE) sin anbefaling fra 2012 ... -
HE4 is a novel tissue marker for therapy response and progestin resistance in medium- and low-risk endometrial hyperplasia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-18)Background: The aim of the present study was to investigate whether changes in the tissue expression of human epididymisspecific protein 4 (HE4) could predict therapy resistance and relapse after progestin hormone therapy for medium- and low-risk endometrial hyperplasia.<p> <p>Methods: Endometrial biopsies were obtained from women participating in a multicentre RCT performed according to the ... -
Head models of healthy and depressed adults for simulating the electric fields of non-invasive electric brain stimulation [version 2; referees: 2 approved]
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-06)During the past decade, it became clear that the electric field elicited by non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized ... -
Head to head comparison of two commercial fecal calprotectin kits as predictor of Mayo endoscopic sub-score and mucosal TNF expression in ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-02)<i>Background</i> - Fecal calprotectin is widely used to monitor disease activity in patients with inflammatory bowel disease. Multiple commercial kits exist, however, since the analyses are not standardized, these kits cannot be used interchangeably. We aimed to perform a technical evaluation of two kits (Calpro from Calprolab, Norway and Calprest from Eurospital, Italy) and perform a tuning for ...
