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Light-curing units used in dentistry: factors associated with heat development – potential risk for patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-01)Objectives:<br>To investigate how heat development in the pulp chamber and coronal surface of natural teeth with and without cusps subjected to irradiance using light-emitting diode (LED)–light-curing units (LCUs) is associated with (i) irradiance, (ii) time, (iii) distance, and (iv) radiant exposure.<br> Materials and methods:<br>Three different LED-LCUs were used. Their irradiance was measured ... -
LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-15)Aims/hypothesis: Activation of inflammatory pathways is involved in the pathogenesis of type 2 diabetes mellitus. On the basis of its role in vascular inflammation and in metabolic disorders, we hypothesised that the TNF superfamily (TNFSF) member 14 (LIGHT/TNFSF14) could be involved in the pathogenesis of type 2 diabetes mellitus. <p>Methods: Plasma levels of LIGHT were measured in two cohorts of ... -
Lightweight methods, heavyweight organisations. Transforming a small tailored product to a large integrated healthcare information system.
(Doctoral thesis; Doktorgradsavhandling, 2012-09-28)The building of large scale information systems in healthcare is a current issue in Norway. Such systems are often built as large systems from the start. This thesis studies another approach: small tailored solutions that grow to become large integrated systems. This thesis adheres to an interpretive research approach, and the empirical material comes from the development of an electronic system for ... -
Likheter og forskjeller i immuniseringen ved hemolytisk sykdom hos foster og nyfødte og føtal/neonatal alloimmun trombocytopeni
(Master thesis; Mastergradsoppgave, 2012-06-01)Bakgrunn: I studien foretas en grundig undersøkelse av likheter og forskjeller mellom hemolytisk sykdom hos foster og nyfødte (HDFN) og føtal/neonatal alloimmun trombocytopeni (FNAIT), spesielt med hensyn til immuniseringsmekanismer og antigen. Målet er å svare på om de immunresponser som resulterer i henholdsvis HDFN og FNAIT er mer like enn tidligere antatt, og om FNAIT kan forebygges med spesifikke ... -
Limb girdle muscular dystrophy type 2I: No correlation between clinical severity, histopathology and glycosylated α-dystroglycan levels in patients homozygous for common FKRP mutation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07)<p>Limb girdle muscular dystrophy type 2I (LGMD2I) is a progressive disorder caused by mutations in the FuKutin-Related Protein gene (FKRP). LGMD2I displays clinical heterogeneity with onset of severe symptoms in early childhood to mild calf and thigh hypertrophy in the second or third decade. Patients homozygous for the common FKRP mutation c.826C>A (p.Leu276Ile) show phenotypes within the milder ... -
The liminal landscape of mentoring - Stories of physicians becoming mentors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-14)<p><i>Introduction:</i> This study explores narratives of physicians negotiating liminality while becoming and being mentors for medical students. Liminality is the unstable phase of a learning trajectory in which one leaves behind one understanding but has yet to reach a new insight or position. <p><i>Methods:</i> In this study, we analysed semi-structural interviews of 22 physician mentors from ... -
Limitations of pig skin as in vitro model mimicking skin with damaged barrier properties
(Master thesis; Mastergradsoppgave, 2013-05-20)Skin is an alternative route for the administration of drugs and has several advantages compared to the oral administration route. However, for a drug substance to act systemically after topical application it has to penetrate through the skin barrier (stratum corneum). Therefore it is important to investigate drug penetration through both healthy and damaged skin (reduced barrier properties). In ... -
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-01)Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal-like subtype associates with increased EGFR signaling, while another, the HER2-enriched subtype, engages a kin of EGFR Based on the premise that EGFR-regulated lncRNAs might ... -
Lindrende senger i sykehjem. En kvalitativ studie om sykepleieres erfaring med tilbudet øremerkede palliative senger i sykehjem
(Master thesis; Mastergradsoppgave, 2018-05-08)Bakgrunn og hensikt: Pasienter med behov for palliativ behandling er karakterisert med mange og komplekse problemer, spesielt i livets sluttfase. Pasientene og de pårørende vil være avhengige av gode tjenester fra alle nivåer i helsetjenesten. Mange kommuner i Norge har valgt å opprette øremerkede senger for palliativ behandling i sykehjem som en del av sitt tilbud til disse pasientene. Data ble ... -
Lindring av smerter hos kreftpasienter
(Research report; Forskningsrapport, 2005)Denne rapporten er en bestilling fra tidligere Sosial-og helsedepartementet om å vurdere kunnskapsgrunnlaget om effekt av palliativ smertebehandling ved kreft, dvs. Effekt av ulike behandlingsmetoder for å lindre smerter hos pasienter med uhelbredelig (ikke-kurabel) kreftsykdom. -
A linear combination of pharmacophore hypotheses as a new tool in search or new active compounds - An application for 5-HT1a receptor ligands
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)This study explores a new approach to pharmacophore screening involving the use of an optimized linear combination of models instead of a single hypothesis. The implementation and evaluation of the developed methodology are performed for a complete known chemical space of 5-HT1AR ligands (3616 active compounds with Ki < 100 nM) acquired from the ChEMBL database. Clusters generated from three different ... -
"Linerla". Kortprosa.
(Others; Andre, 2012) -
Linking brain networks and behavioral variability to different types of mind-wandering
(Others; Andre, 2017-07-13) -
Linking interprofessional work to outcomes for employees: A meta‐analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-14)The aim of this meta‐analysis of studies of workers in the health and social care sector was to examine the relationship between interprofessional work and employee outcomes of job stress, autonomy, burnout, engagement, job satisfaction, turnover intention, and perceived service quality, and to examine the influence of different moderators on those relationships. A systematic literature search of ... -
Links between chemsex and reduced mental health among Norwegian MSM and other men: results from a cross-sectional clinic survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-25)<i>Background</i> - The use of specific drugs to facilitate, enhance or prolong sexual sessions is referred to as ‘chemsex’. The popularity of the behavior seems to be growing, but there is a paucity of information on the mental health aspects associated with chemsex and no data on chemsex from Nordic countries. We investigated the link between chemsex and mental health among men who have sex with ... -
Links between transactional sex and HIV/STI-risk and substance use among a large sample of European men who have sex with men
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-05)<i>Background</i> - In Europe, the highest proportion of HIV diagnoses are in gay men and other men who have sex with men (MSM). Globally, HIV prevalence is particularly high among males who report selling sex, but rates among men who buy sex from other men are less clear. This study analyzed the association of transactional sex (TS) and HIV diagnosis, sexually transmitted infection (STI) diagnoses, ... -
Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-14)Background - The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI.<p> <p>Methods and Results - Longitudinal data on serum lipid levels for 26 130 individuals (50.5% women, aged 20–89 years) were obtained ... -
Lipidklasser og fettsyresammensetning i brunpølse (Cucumaria frondosa)
(Master thesis; Mastergradsoppgave, 2011-05-20)Different species of the sea cucumber are a well utilized resource in eastern parts of Asia, but not much used in western parts of the world. The annual harvest of sea cucumbers in Asian waters has been estimated to be over 100,000 tons. This has led to overfishing and decreasing catches. As a result, a demand for new fishing areas has occurred. Different species of sea cucumbers are observed in ... -
Lipidklasser og fettsyresammensetning i omega-3 produkter
(Master thesis; Mastergradsoppgave, 2012-05-20)Nasjonalt råd for ernæring anbefaler å spise fisk og sjømat fordi de innholder de flerumettede omega-3 fettsyrene eikosapentaensyre (EPA: 20:5n-3) og dokosahekaensyre (DHA: 22: 6n-3). Mye forskning viser kobling mellom omega-3 fettsyrene og helsegevinster. Helsegevinstene er at disse fettsyrene er betennelsesdempende, de reduserer risiko for å utvikle sykdommer som revmatoid artritt, hjerte -kar ... -
Lipidomics in ulcerative colitis reveal alteration in mucosal lipid composition associated with the disease state
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-11)<p><i>Background - </i>The onset of ulcerative colitis (UC) is associated with alterations in lipid metabolism and a disruption of the balance between pro- and anti-inflammatory molecules. Only a few studies describe the mucosal lipid biosignatures during active UC. Moreover, the dynamics of lipid metabolism in the remission state is poorly defined. Therefore, this study aims to characterize mucosal ...
